PDE5 shRNA对心肌细胞凋亡的保护作用(2)
![]() |
第1页 |
参见附件。
总之,PDE5 shRNA明显拮抗缺氧缺糖诱导的心肌细胞凋亡,通过持续抑制心肌细胞PDE5基因表达对缺氧缺糖条件下心肌细胞发挥显著的保护作用。
参考文献
[1] Lockshin RA.Programmed cell death:history and future of a Concept[J].J Soc Biol,2005,199(3):169-173.
[2] Pokreisz P,Vandenwijngaert S,Bito V,et al.Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice[J].Circulation,2009,(119):408-416.
[3] Bernstein E,Caudy AA,Hammond SM ......
您现在查看是摘要介绍页,详见PDF附件。