HPLC法测定复方奥美拉唑碳酸氢钠氢氧化镁咀嚼片中奥美拉唑的含量
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【摘 要】目的：建立复方奥美拉唑碳酸氢钠氢氧化镁咀嚼片含量测定方法。方法：采用HPLC法测定复方奥美拉唑碳酸氢钠氢氧化镁咀嚼片中奥美拉唑的含量。结果：奥美拉唑在4.6～46μg ·mL- 1浓度范围内与峰面积呈良好的线性关系；平均回收率为99.93%， R SD为0.67%(n=9)。结论：本法专属性强，灵敏度高，重复性好，可用于复方奥美拉唑碳酸氢钠氢氧化镁咀嚼片的质量控制。
【关键词】复方奥美拉唑碳酸氢钠氢氧化镁咀嚼片；奥美拉唑；高效液相色谱法
【中图分类号】R 927.2 【文献标识码】A 【文章编号】1004- 7484(2012)05- 0259- 02
Determination of Omepraxole in Omeprazole Sodium bicarbonate Magnesium hydrate Chewable Tablets by HPLC
HUANG Yi(Hunan Provincial Hospital for Women and Children, Changsha 410008, China)
【Abstract】Objective：To establish the determination method for Omeprazole Sodium bicarbonate Magnesium hydrate Chewable Tablets.Methods：The content of omeprazole was determined by HPLC.Results：The calibration curve 0f omeprazole was linear at 4.6～46μg ·mL-1，the average recovery was 99.93%,and RSD was 0.67% (n=9).Conclusion：The method is selective，sensitive and reproducibile，which can be used for the quality control of Omeprazole Sodium bicarbonate Magnesium hydrate Chewable Tablets.
【Key word】Omeprazole Sodium bicarbonate Magnesium hydrate Chewable Tablets ; Omeprazole; HPLCCLC number: R Document code:A Article ID:
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