概述甲胎蛋白综述(2)
第1页 |
参见附件。
目前临床上AFP多用于肝癌的筛查、诊断、预后及疗效观察。但鉴于其灵敏度、特异度较低,寻找灵敏度更高,具有早期诊断肝癌和更准确预测肝癌复发的指标迫在眉睫。AFP异质体有助于良性肝病与肿瘤、肝癌与其他肿瘤的鉴别,但仍有待大规模研究进一步明确其临床意义。
参考文献
[1] Debruyne E N, Delanghe J R. Diagnosing and monitoring hepatocellular carcinoma with alpha-fetoprotein: new aspects and applications.[J]. Clin Chim Acta. 2008, 395(1-2): 19-26.
[2] Sell S. Alpha-fetoprotein, stem cells and cancer: how study of the production of alpha-fetoprotein during chemical hepatocarcinogenesis led to reaffirmation of the stem cell theory of cancer.[J]. Tumour Biol. 2008.
[3] 李河憬. 甲胎蛋白和肝病的相关性分析[D]. 吉林大学硕士学位论文, 2007.
[4] 常彬霞, 辛绍杰. 甲胎蛋白及其临床应用研究进展[J]. 世界华人消化杂志, 2010.02.28, 18(06): 576-580
[5] 王宏波, 张军, 丁光辉, 等. 甲胎蛋白与胃癌[J]. 中国普外基础与临床杂志, 2008, (07).
[6] Pang R W. Biology of hepatocellular carcinoma.[J]. Ann Surg Oncol. 2008.
[7] Reichman T, Koneru B, Fisher A, et al. Race and AFP levels predict survival in patients with hepatocellular carcinoma[J]. Annals of Surgical Oncology. 2004, 11(0): 107-108.
[8] Saffroy R, Pham P, Reffas M, et al. New perspectives and strategy research biomarkers for hepatocellular carcinoma.[J]. Clin Chem Lab Med. 2007, 45(9): 1169-1179.
[9] Babali A, Cakal E, Purnak T, et al. Serum alpha-fetoprotein levels in liver steatosis.[J]. Hepatol Int. 2009.
[10] Brock D J, Sutcliffe R G. Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida.[J]. Lancet. 1972, 2(7770): 197-199.
作者简介:
林彬彬,女,28岁;工作单位:厦门市中医院;职称:住院医师
您现在查看是摘要介绍页,详见PDF附件。