【摘 要】目的：探讨不同浓度的葡萄糖溶液对蟾蜍坐骨神经-腓肠肌收缩活动的影响。方法：选取蟾蜍坐骨神经-腓肠肌标本作为研究对象，采用电生理方法，测定不同浓度葡萄糖(葡萄糖溶液分别为50g/L、100g/L、150g/L及200g/L)在作用于坐骨神经的条件下，对骨骼肌收缩力的影响。并以甘露醇(浓度为20%)作为对照组进行比较，将对比的结果进行回顾性分析。结果：不同浓度的葡萄糖溶液对骨骼肌收缩的幅度均有不同程度影响，对骨骼肌收缩力的抑制作用越明显。高渗葡萄糖溶液对肌肉收缩起抑制作用，在一定范围内，抑制效果与浓度高低成正相关。结论：高浓度葡萄糖作为高渗透压，导致神经脱水，阻滞神经传导，进而抑制肌肉收缩。

    【关键词】葡萄糖；蟾蜍；坐骨神经-腓肠肌；肌肉收缩

    The effect of different concentration of glucose solution on the contraction of the sciatic nerve - gastrocnemius.

    Abstract Objective： To explore the effect of different concentration of glucose solution on the contraction of the sciatic nerve-gastrocnemius. Methods The effects of different concentrations of glucose (50 g / L ～ 100 g / L ～ (150 g / L) and 200 g / L) on the contractility of skeletal muscle were measured by electrophysiological method in toad sciatic nerve and gastrocnemius muscle specimens.Mannitol (20%) was used as control group and the results were analyzed retrospectively.Results Different concentrations of glucose solution had different effects on the contraction amplitude of skeletal muscle ......