The Determination of the Minimum Safe Level of Interleukin 10IL—10 in (5)
My proposal
A 2017 study along with numerous of studies in 2010-2015 have showed that IL-10， especially CD4+T cells and CD8+T cells derived IL-10， can suppress the immune response to Mtb infections(14，19-21，25). In addition， monocyte-derived IL-10， which is the most important source of IL-10 in Mtb infection， did not show significant effect in suppressing the immune response to Mtb infections(25). So， we can try to preserve monocyte-derived IL-10 production after Mtb infection to reduce the potentially side effects.
, 百拇医药
In addition， a 2017 study showed that the inhibition of IL-10 for a short period of time in treating tumors may not cause serious side effects(23). However， inhibiting or even reducing IL-10 signaling for a long period of time is very likely to cause serious side effects such as enteritis and rheumatic arthritis. So， I think a study to determine whether inhibit IL-10 signaling for even a short period of time， such as when injecting therapeutic vaccines or using anti-tuberculosis， will cause side effects in Mtb infections is urgent needed. If yes， then experiments that can determine the minimum concentration of IL-10 in human(maybe can use non-human primates model to determine) that is safe and also， at the same time， maximize the enhancement effect to T cells against TB infection is needed. If no， then the determination of the longest safe blockage time is needed.
, 百拇医药
Moreover， once determined， the safe range will be an important reference factor in future IL-10 inhibitor development for TB infections. Nonetheless， whether IL-10 inhibitor developed for TB will lead to serious side effect when applying to other diseases is remain unclear and therefore need further study. In conclusion， either possible situations need study immediately. Therefore， I proposed that the establishment of a laboratory team studying in this theme is important and needs quick action.
, 百拇医药
Also， the intake method may affect the efficacy of many tuberculosis drugs and vaccines， therefore very likely to including the potential IL-10 inhibitor. If the drugs are taken by oral or intramuscular， the effective factors need to travel longer to reach the place of Mtb infection though blood vessels indirectly. In contrast， an inhaled IL-10 inhibitor can reach the infected place quickly and directly， which may result in reaching the effective concentration quicker and better efficacy.
, http://www.100md.com
Finally， although we cannot just simply assumes that the inhibit of IL-10 can work for all diseases， however， IL-10 shows immunosuppression effects not only in Mtb infection， but also in a lot of other diseases such as toxoplasmosis (22)， leishmaniasis (23)， and malaria(24).Therefore， I suggest that maybe we should conduct efficacy-determine tests to see if the inhibition of IL-10 when the vaccine inject or drugs taken can enhance vaccines' efficacy., 百拇医药(ChangTai. Li)
A 2017 study along with numerous of studies in 2010-2015 have showed that IL-10， especially CD4+T cells and CD8+T cells derived IL-10， can suppress the immune response to Mtb infections(14，19-21，25). In addition， monocyte-derived IL-10， which is the most important source of IL-10 in Mtb infection， did not show significant effect in suppressing the immune response to Mtb infections(25). So， we can try to preserve monocyte-derived IL-10 production after Mtb infection to reduce the potentially side effects.
, 百拇医药
In addition， a 2017 study showed that the inhibition of IL-10 for a short period of time in treating tumors may not cause serious side effects(23). However， inhibiting or even reducing IL-10 signaling for a long period of time is very likely to cause serious side effects such as enteritis and rheumatic arthritis. So， I think a study to determine whether inhibit IL-10 signaling for even a short period of time， such as when injecting therapeutic vaccines or using anti-tuberculosis， will cause side effects in Mtb infections is urgent needed. If yes， then experiments that can determine the minimum concentration of IL-10 in human(maybe can use non-human primates model to determine) that is safe and also， at the same time， maximize the enhancement effect to T cells against TB infection is needed. If no， then the determination of the longest safe blockage time is needed.
, 百拇医药
Moreover， once determined， the safe range will be an important reference factor in future IL-10 inhibitor development for TB infections. Nonetheless， whether IL-10 inhibitor developed for TB will lead to serious side effect when applying to other diseases is remain unclear and therefore need further study. In conclusion， either possible situations need study immediately. Therefore， I proposed that the establishment of a laboratory team studying in this theme is important and needs quick action.
, 百拇医药
Also， the intake method may affect the efficacy of many tuberculosis drugs and vaccines， therefore very likely to including the potential IL-10 inhibitor. If the drugs are taken by oral or intramuscular， the effective factors need to travel longer to reach the place of Mtb infection though blood vessels indirectly. In contrast， an inhaled IL-10 inhibitor can reach the infected place quickly and directly， which may result in reaching the effective concentration quicker and better efficacy.
, http://www.100md.com
Finally， although we cannot just simply assumes that the inhibit of IL-10 can work for all diseases， however， IL-10 shows immunosuppression effects not only in Mtb infection， but also in a lot of other diseases such as toxoplasmosis (22)， leishmaniasis (23)， and malaria(24).Therefore， I suggest that maybe we should conduct efficacy-determine tests to see if the inhibition of IL-10 when the vaccine inject or drugs taken can enhance vaccines' efficacy., 百拇医药(ChangTai. Li)