【摘 要】：背景：扩大的血管周围间隙作为脑小血管病的标志之一，与卒中不良预后密切相关。目的：本文旨在探讨扩大写血管周围间隙(Enlarged perivascular spaces ，EPVS)与卒中后抑郁(poststroke depression，PSD)的相关性。方法：招募2017-2018年急性缺血性卒中患者，入院后完善头颅磁共振检查并对EPVS进行分级。3个月后随访患者进行GSD-15量表评分并根据《中国精神障碍分类与诊断标准》进行PSD诊断，分析EPVS和PSD之间的相关性。结果：EPVS的严重程度与PSD独立相关。

    【关键词】：缺血性卒中、血管周围间隙、卒中后抑郁、磁共振

    Abstract： Background： Enlarged perivascular spaces (EPVS)are associated with unfavorable prognosis of stroke. Objiective：This study explored the relationship between EPVS and post-stroke depression(PSD). Methods： A total of 352 patients with acute ischemic stroke were recruited from the people hospital of laiwu from2017 to 2018. The extent of EPVS in the basal ganglia (BG) and the centrum semiovale (CS) was assessedon axial T2 weighted magnetic resonance imaging using a validated scale. PSD was defined as a Geriatric Depression Scale score of ≥ 7 assessed at threemonths after stroke. The association between EPVS and PSD was examined with logistic regression. Conclusions： The severity of EPVS is associated with PSD independently. ......