【摘 要】 目的： 探讨成都市双流地区慢性萎缩性胃炎患者幽门螺杆菌(Hp)的耐药情况及Hp细胞毒素相关基因A(cagA)与萎缩性胃炎关系。方法：对200株临床分离菌株，进行培养及纸片扩散法药敏试验，采用PCR法检测Hp的cagA基因。结果：成都双流地区Hp对阿莫西林、呋喃唑酮、甲硝唑、替硝唑、克拉霉素的耐药率分别为12.5%、1%、65%、10%和14%，HP菌株cagA基因的阳性率为74.5%。结论：本地区阿莫西林、呋喃唑酮、克拉霉素、替硝唑可作为根除Hp的一线药物。本地区Hp感染菌株以cagA基因型为主，该基因型Hp感染与萎缩性胃炎发生密切相关。

    【关键词】 幽门螺杆菌;慢性萎缩性胃炎;耐药性;cagA基因

    【中图分类号】R573.3+ 2【文献标志码】A【文章编号】1005-0019(2019)09-018-01

    Abstract Objective： TO investigate the resistance profile of Helicobacter pylori associated chronic atrophic gastritis and the relationship between cagA gene.Methods： A total of 200 H.pylori isolates were cultured and tested for cagA gene by PCR.The susceptibility testing was done by disk diffusion technique.Results ：The percentage of H.pylori isolates resistant to amoxicillin ......