右美托咪定对瑞芬太尼麻醉痛觉过敏的影响评价(1)
【摘要】目的：探讨右美托咪定对于瑞芬太尼麻醉痛觉过敏的影响。方法：选择我院接受治疗的50例腹腔手术患者作为研究对象，按照随机分组法将其分为对照组和实验组，每组患者有25例，其中实验组患者接受麻醉诱导后分别实施右美托咪定，对照组患者则接受等量生理盐水，两组患者都接受瑞芬太尼并吸入七氟醚实现麻醉维持，控制BIS值在40到60之间。患者手术之后都接受芬太尼PCIA以，并且在PACU进行2h观察，对患者术后VAS评分和镇痛泵按压次数以及芬太尼用量进行记录和观察。结果：实验组患者和对照组患者相比较PACU后首次VAS评分超过4分的VAS评分明显减少，PACU时PCIA用量明显减少，术后24h、48hPCIA泵按压次数明显较少。两组患者总体差异较为明显(P<005)，具有统计学意义。结论：术中静注右美托咪定能够在一定程度减少患者术后出现的疼痛感，避免不必要的药物剂量，还能够减少瑞芬太尼导致的患者出现的痛觉过敏问题，并且不会对患者麻醉苏醒质量造成影响，值得在临床手术中使用和推广。
【关键词】右美托定；瑞芬太尼；痛觉过敏
【中图分类号】R249
【文献标志码】A
【文章编号】
1005-0019(2019)16-008-01
Evaluation of the effect of dexmedetomidine on anorexia allergy in remifentanil
Zhang Anjun
(Rizhao City Hospital of Traditional Chinese Medicine Rizhao City， Shandong 276800)
Abstract
Objective： To investigate the effect of dexmedetomidine on hyperalgesia in remifentanil. Methods： Fifty patients with abdominal surgery who underwent treatment in our hospital were enrolled in the study. They were divided into control group and experimental group according to randomization method. There were 25 patients in each group， and the experimental group received right anesthesia after induction. Tomididine， the control group received the same amount of normal saline， both groups received remifentanil and inhaled sevoflurane for anesthesia maintenance， control BIS values between 40 and 60 Patients underwent fentanyl PCIA after surgery and were observed in the PACU for 2 hours. The postoperative VAS score and the number of analgesic pump presses and the amount of fentanyl were recorded and observed. Results： Compared with the control group， the VAS score of the first VAS score of more than 4 points after PACU was significantly reduced. The amount of PCIA was significantly decreased in PACU， and the number of PCIA pump presses was significantly less at 24h and 48h after operation. The overall difference between the two groups was more significant (P<005)， which was statistically significant. Conclusion： Intraoperative intravenous dexmedetomidine can fundamentally relieve postoperative pain， reduce the amount of postoperative analgesic drugs， and reduce the hyperalgesia induced by remifentanil， and will not anesthetize patients. Awakening quality has an impact and is worthy of use and promotion in clinical surgery.
Key words：
dexmedodine； remifentanil； hyperalgesia
瑞芬太尼作為持续无积蓄、恢复时间短、起效相对较快的阿片类药物，患者在使用之后可能会出现程度不一的痛觉过敏现象，而右美托咪定则属于高效、高选择性的肾上腺素受体激动药，除了能够发挥出镇静、抗焦虑等功效之外，还具有显著的镇痛疗效，当前该种药物一般应用在维持麻醉中，但是，是否能够从根本上减少患者术后的疼痛感还不知晓[1]。为了进一步探讨右美托咪定对于瑞芬太尼麻醉痛觉过敏的影响，现选择我院接受治疗的50例腹腔手术患者作为研究对象，并将其总结报道如下。, http://www.100md.com(张安军)
【关键词】右美托定；瑞芬太尼；痛觉过敏
【中图分类号】R249
【文献标志码】A
【文章编号】
1005-0019(2019)16-008-01
Evaluation of the effect of dexmedetomidine on anorexia allergy in remifentanil
Zhang Anjun
(Rizhao City Hospital of Traditional Chinese Medicine Rizhao City， Shandong 276800)
Abstract
Objective： To investigate the effect of dexmedetomidine on hyperalgesia in remifentanil. Methods： Fifty patients with abdominal surgery who underwent treatment in our hospital were enrolled in the study. They were divided into control group and experimental group according to randomization method. There were 25 patients in each group， and the experimental group received right anesthesia after induction. Tomididine， the control group received the same amount of normal saline， both groups received remifentanil and inhaled sevoflurane for anesthesia maintenance， control BIS values between 40 and 60 Patients underwent fentanyl PCIA after surgery and were observed in the PACU for 2 hours. The postoperative VAS score and the number of analgesic pump presses and the amount of fentanyl were recorded and observed. Results： Compared with the control group， the VAS score of the first VAS score of more than 4 points after PACU was significantly reduced. The amount of PCIA was significantly decreased in PACU， and the number of PCIA pump presses was significantly less at 24h and 48h after operation. The overall difference between the two groups was more significant (P<005)， which was statistically significant. Conclusion： Intraoperative intravenous dexmedetomidine can fundamentally relieve postoperative pain， reduce the amount of postoperative analgesic drugs， and reduce the hyperalgesia induced by remifentanil， and will not anesthetize patients. Awakening quality has an impact and is worthy of use and promotion in clinical surgery.
Key words：
dexmedodine； remifentanil； hyperalgesia
瑞芬太尼作為持续无积蓄、恢复时间短、起效相对较快的阿片类药物，患者在使用之后可能会出现程度不一的痛觉过敏现象，而右美托咪定则属于高效、高选择性的肾上腺素受体激动药，除了能够发挥出镇静、抗焦虑等功效之外，还具有显著的镇痛疗效，当前该种药物一般应用在维持麻醉中，但是，是否能够从根本上减少患者术后的疼痛感还不知晓[1]。为了进一步探讨右美托咪定对于瑞芬太尼麻醉痛觉过敏的影响，现选择我院接受治疗的50例腹腔手术患者作为研究对象，并将其总结报道如下。, http://www.100md.com(张安军)