【摘要】多种疾病状态如高血压、糖尿病、高血糖症等使体内活性氧的生成速度大于其清除速度，活性氧在体内积聚，导致一系列生物氧化反应。氧化应激在动脉粥样硬化发生发展过程中起重要作用。本文从活性氧对血管壁的影响、活性氧与内质网应激的关系，对动脉粥样硬化发生与发展的分子机制加以综述

    【关键词】氧化应激 动脉粥样硬化 内质网应激

    中图分类号：R543文献标识码：B文章编号：1005-0515(2011)8-388-02

    【Abstract】Many diseases such as hypertension， diabetes， high blood sugar disorders produce too much reactive oxygen species (ROS)， resulting in oxidative stress. Recent studies have found that oxidative stress play an important role in the process of atherosclerosis. Of ROS the effects on vascular walls and the relationship with endoplasmic reticulum stress are reviewed.

    【Key words】oxidative stress; atherosclerosis; endoplasmic reticulum stress

    动脉粥样硬化(atherosclerosis ......