炎症因子与Graves病及并发症的关系(1)
 |
| 第1页 |
参见附件(2893KB，2页)。
【摘要】目的 研究炎症因子高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)与 Graves病(GD)的关系。方法 比较正常对照组和GD组hsCRP、TNF-α的水平，观察GD治疗前及治疗后2周、1月、2月、3月hs-CRP、游离甲状腺激素(FT3、FT4)的变化，比较丙基硫氧嘧啶(PTU)或赛治(MM)治疗hs-CRP有何差别，比较GD不同并发症者hs-CRP水平。结果 正常对照组hsCRP0.512±0.338(mg/L)，TNF-α 0.530±0.564(μg/L)， GD 组hsCRP 2.052±2.778 (mg/L)，TNF-α 1.247±2.206(μg/L)，两组比较差异有非常显著性意义p均<0.001。GD者治疗2周hs-CRP明显下降，直至3月内均处于缓慢下降，治疗前与治疗后各时段(2周、1月、2月、3月)hs-CRP相比有统计学意义(p分别为0.001，<0.001，0.002，0.001)，用PTU与用MM治疗相比，hs-CRP无统计学意义(P>0.05)。 hs-CRP均值:甲亢危象组>甲心病组>浸润性突眼组>普通甲亢组>肝损害组>低钾周麻组>白细胞减低组。结论 GD患者炎症因子hsCRP、TNF-α明显高于正常人，GD并发症越严重hs-CRP水平越高，提示炎症与GD的发病和病情严重程度密切相关。
【关键词】Graves病 并发症 高敏C反应蛋白 肿瘤坏死因子
中图分类号：R771.3文献标识码：B文章编号：1005-0515(2011)11-058-02
【Abstract】Objective To study the high-sensitivity C reactive inflammatory protein (hs-CRP), tumor necrosis factor-α (TNF-α) and Graves disease (GD) relationship. Comparison of the normal control group and the GD group of hsCRP, TNF-α levels observed after treatment of GD before treatment and 2 weeks, 1 month, February, March hs-CRP, free thyroid hormones (FT3, FT4) changes, compared Propylthiouracil (PTU) or race rule (MM) treatment of the difference between hs-CRP compared with different complications GD hs-CRP levels. Results In the normal control group, hsCRP 0.512±0.338 (mg/L), TNF-α 0.530±0.564(μg/L), GD Group hsCRP 2.052±2.778 (mg / L), TNF-α 1.247±2.206 (μg/L), The difference between the two groups is statistically significant p all <0.001. GD were treated for 2 weeks significantly decreased hs-CRP, until 3 in the slow decline during the month before treatment and after treatment at various time intervals (2 weeks, 1 month, 2 month and 3 months) hs-CRP compared to statistical significance(p0.001, respectively, "0.001,0.002,0.001), treatment with PTU, compared with the use of MM, hs-CRP was not significant (P> 0.05). Mean hs-CRP: thyroid crisis group> A Heart Group> infiltrative exophthalmos Group> General hyperthyroid group> liver injury group> low potassium weeks anesthesia group> WBC reduction group. Conclusion GD patients with inflammatory factors hsCRP, TNF-α was significantly higher than normal, GD more serious complications, the higher the hs-CRP levels, suggesting that inflammation and the incidence of GD and severity are closely related ......
您现在查看是摘要介绍页，详见PDF附件(2893KB，2页)。