营养不良与认知功能障碍的研究进展(2)
然而,认知功能障碍中营养相关危险因子的证据仍不充分。严重或中度营养不良看似可以增加痴呆的易感性。然而,适当的营养也未能完全保护这些易感个体患病。另外,大量证据均表明必需微量营养素缺乏可导致认知功能障碍,但该营养素缺乏的界限值未能具体给出。此外,我们仍需大量随机,双盲及安慰剂对照试验来评估营养素缺乏对认知功能障碍的潜在影响[11]。这些都是我们今后对于营养不良与认知功能障碍研究的方向和重点所在。
参考文献
[1] 李舜伟.认知功能障碍的诊断与治疗[J].中国神经精神疾病杂志,2006,32(2):189-191.
[2] 孙贵范.预防医学[M].北京:人民卫生出版社,2001:32.
[3]World Health Organization. Malnutrition—The Global Picture,2000; Available at: http://www.who.int/home-page/ [Full Text].
, 百拇医药
[4]邱田,蒙华庆. 双相情感障碍的认知功能研究进展[J].重庆医学.2009,38(8):995.
[5]Osamu Nakagawasai,Fumihiro Yamadera,Shoko Sato.et al. Alterations in cognitive function in prepubertal mice with protein malnutrition: Relationship to changes in choline acetyltransferase[J]. Behavioural Brain Research,2006,167:111–117.
[6]Fadda F, Cocco S, Stancampiano R. Hippocampal acetylcholine release correlates with spatial learning performance in freely moving rats. Neuroreport.2000,11:2265–9.
, 百拇医药
[7]Lai, M.K.,Tsang, S.W.,Francis, P.T.et al. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain Res,2003,974:82-87.
[8]Liu J, Raine A .The effect of childhood malnutrition on externalizing behavior. Curr Opin Pediatr,2006,18:565–570.
[9]Bourre JM . Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2:macronutrients. J Nutr Health Aging.2006, 10:386–399.
, http://www.100md.com
[10] J. Micheau, T.P. Durkin, C. Destrade et al. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation, Pharmacol. Biochem. Behav. 1985,23:195–198.
[11] Angelo Del Parigi a, Francesco Panza b, Cristiano Capurso et al.Nutritional factors, cognitive decline, and dementia Brain Research Bulletin.2006,69: 1–19.
[12] Frederickson.C, Dansche Gt.Zinc-containing neurons in hippocampus and related CNS structures.Prog Brain Res.1990,83:71.
, 百拇医药
[13] 洪琦.铁缺乏症儿童的行为改变[J].国外医学儿科学分册,1991,18(2):74.
[14] 沈晓明,严崇淮,许积德等.缺铁性贫血对幼鼠学习记忆行为的影响[J].中华儿科杂志,1994,32(5):267.
[15] 肖小华,张静,杨俊卿. 慢性铝过负荷致大鼠认知功能损伤及尼莫地平保护作用观察[J].第三军医大学学报,2007,29(11):1030-1031.
[16] Aron M. Troen, Melissa Shea-Budgell, Barbara Shukitt-Hale et al. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. PNAS 2008, 105(34):12474–12479., 百拇医药(陈剑飞 王永红)
参考文献
[1] 李舜伟.认知功能障碍的诊断与治疗[J].中国神经精神疾病杂志,2006,32(2):189-191.
[2] 孙贵范.预防医学[M].北京:人民卫生出版社,2001:32.
[3]World Health Organization. Malnutrition—The Global Picture,2000; Available at: http://www.who.int/home-page/ [Full Text].
, 百拇医药
[4]邱田,蒙华庆. 双相情感障碍的认知功能研究进展[J].重庆医学.2009,38(8):995.
[5]Osamu Nakagawasai,Fumihiro Yamadera,Shoko Sato.et al. Alterations in cognitive function in prepubertal mice with protein malnutrition: Relationship to changes in choline acetyltransferase[J]. Behavioural Brain Research,2006,167:111–117.
[6]Fadda F, Cocco S, Stancampiano R. Hippocampal acetylcholine release correlates with spatial learning performance in freely moving rats. Neuroreport.2000,11:2265–9.
, 百拇医药
[7]Lai, M.K.,Tsang, S.W.,Francis, P.T.et al. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain Res,2003,974:82-87.
[8]Liu J, Raine A .The effect of childhood malnutrition on externalizing behavior. Curr Opin Pediatr,2006,18:565–570.
[9]Bourre JM . Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2:macronutrients. J Nutr Health Aging.2006, 10:386–399.
, http://www.100md.com
[10] J. Micheau, T.P. Durkin, C. Destrade et al. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation, Pharmacol. Biochem. Behav. 1985,23:195–198.
[11] Angelo Del Parigi a, Francesco Panza b, Cristiano Capurso et al.Nutritional factors, cognitive decline, and dementia Brain Research Bulletin.2006,69: 1–19.
[12] Frederickson.C, Dansche Gt.Zinc-containing neurons in hippocampus and related CNS structures.Prog Brain Res.1990,83:71.
, 百拇医药
[13] 洪琦.铁缺乏症儿童的行为改变[J].国外医学儿科学分册,1991,18(2):74.
[14] 沈晓明,严崇淮,许积德等.缺铁性贫血对幼鼠学习记忆行为的影响[J].中华儿科杂志,1994,32(5):267.
[15] 肖小华,张静,杨俊卿. 慢性铝过负荷致大鼠认知功能损伤及尼莫地平保护作用观察[J].第三军医大学学报,2007,29(11):1030-1031.
[16] Aron M. Troen, Melissa Shea-Budgell, Barbara Shukitt-Hale et al. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. PNAS 2008, 105(34):12474–12479., 百拇医药(陈剑飞 王永红)