析因设计在LASIK残留角膜基质床厚度影响因素研究中的应用(1)

http://www.100md.com 2011年3月1日 高玮 丁亚梅 满辉

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     [摘要] 目的 采用析因设计法探索LASIK残留角膜基质床厚度的主要影响因素的关联及其该设计方法的实用性。方法 从近三年来医院眼科接受LASIK患者中抽取病例，以术前眼压、屈光度数、术后残留角膜基质床厚度为主要研究因素进行析因设计(factorial design)试验。结果 术前屈光度间、术前眼压与术前屈光度间差异无意义(p>0.05)；其余均有统计学差异(p<0.05或P<0.01)；术前眼压、屈光度、术后角膜基质床厚度间存在交互影响(P<0.01)，说明此三因素对手术成功与否有直接关系。结论 在术前眼压低于21mmHg、术前屈光度中度、术后残留角膜基质床厚度保留300μm及以上最安全，析因设计方法同样适用于眼科专业中多因素多水平的研究。

    [关键词] 析因设计； 角膜基质； 准分子激光原位角膜磨镶术； 影响因素

    [中图分类号] R772.2[文献标识码] A[文章编号] 1005-0515(2011)-03-009-02

    Application of factorial design in study about influence factors of thickness of residual corneal stroma bed After LASIK

    GAO Wei，Ding Ya-Mei，Man-Jun

    (Department of Ophthalmology, The Dongfang Hospital of The First people Hospital，Lianyungang of Jiangsu ，Lianyungang 222042，China)

    [Abstract] Objective To apply factorial design to ascertain the thickness of residual corneal stroma bed after the laser in situ keratomileusis (LASIK) and the relevance with the main influence factors and at function. Methods Cases were randomly selected from patients treated with LASIK in ophthalmic hospital recent three years. Do factorial design experiments with the main study factors such as preoperative intraocular pressure, degrees of refraction and thickness of postoperative residual corneal stroma bed. Results The differences between Preoperative dioptres are meaningless, the differences between Preoperative dioptre and preoperative intraocular pressure are meaningless too (p>0.05), and there are statistical differences in others. There are interaction among preoperative intraocular pressure, preoperative dioptre and thickness of postoperative residual corneal stroma bed (p<0.05), and this means the three factors can influence the surgical results. Conclusion It will be safety if preoperative intraocular pressure under 21mmHg, moderate preoperative dioptre and thickness of postoperative residual corneal stroma bed above 300μm ......

    http://www.100md.com/html/paper/1005-0515B/2011/03/07.htm

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