血清脑钠肽检测在老年人甲亢性心脏病中的应用(1)
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[摘要] 目的 探讨血清脑钠肽(BNP)检测在老年人甲亢性心脏病(甲亢心)中的应用。方法 测定并比较甲亢心40例(甲亢心组)，甲状腺功能亢进症(甲亢组)及对照组各40例老年人的血清BNP、左室射血分数(LVEF)，二尖瓣血流频谱E/A比值等指标，并以BNP为诊断指标。结果 ①甲亢心组和甲亢组患者治疗前血清BNP水平均显著高于对照组(P<0.05)，LVEF及E/A比值明显低于对照组(P<0.05)，甲亢心组血清BNP水平与TT3、TT4水平呈显著正相关(r=0.703,P<0.05;r=0.569,P<0.05)，与LVEF、E/A比值呈显著负相关(r=-0.46,P<0.05,r=-0.33,P<0.05)。②甲亢心组和甲亢组患者治疗6个月后血清BNP、TT3、TT4显著低于治疗前(P<0.05)， LVEF、E/A比值显著高于治疗前(P<0.05)。结论 血清BNP检测是老年人甲亢心比较可靠的检测指标,其水平的高低结合LVEF、E/A比值可反映甲亢心的严重程度以及心肌损害的程度。
[关键词] 脑钠肽； 甲亢性心脏病； 心功能； 老年人
[中图分类号] R541.8+5 [文献标识码] B [文章编号] 1005-0515(2012)-01-020-02
Application of Serum Brain Natriuretic Peptide in the Diagnosis of Hyperthyroid heart Disease in the Elderly
Yin Yuanwan1 Xiang Bin1 Xiang Yuhua2
(1The Endocrine Department of Central Hospital of Enshi,Hubei, Enshi,445000;2The Obstetrics and gynecology department
of Central Hospital of Enshi,Hubei,Enshi,445000 china)
[Abstract] Objective To evaluate the Application of serum brain natriuretic peptide(BNP)in the diagnosis of hyperthyroid heart disease in the elderly.Methods eighty elderly with hyperthyroidism were assigned to two groups according to their cardiac functions: hyperthyroid heart disease(n=40)and hyperthyroidism alone(n=40).Forty healthy elderly served as the control group. Serum BNP leve, l left ventricular ejection fraction(LVEE)and E/A ratio were measured before and after treatment. The diagnostic value of BNP was evaluated in elderly with hyperthyroid heart disease. Results The serum BNP level in the hyperthyroid heart disease and the hyperthyroidism alone groups before treatment was significantly higher than that in the control group(P<0.05), while the LVEF and the E/A ratio were significantly lower than those in the control group(P<0.05).Serum BNP level was positively correlated with the TT3(r=0.703,P<0.05)andTT4levels(r=0.569,P<0.05)and negatively with the LVEF(r=-0.46,P<0.05)and the E/A ratio(r=-0.33,P<0.05)in the hyperthyroid heart disease group. The serum BNP,TT3 and TT4levels in the hyperthyroid heart disease and the hyperthyroidism alone groups were reduced and the LVEF and the E/A ratio increased significantly six months after treatment(P<0 ......
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