黄芪颗粒治疗急性哮喘患儿的临床疗效及对内皮素的影响(1)
 |
| 第1页 |
参见附件。
【摘要】目的：探讨黄芪颗粒治疗急性哮喘病儿临床疗效及治疗前后血浆内皮素的影响。方法：选择哮喘急性发期儿童患者68例，均给予相对应级别剂量的糖皮质激素吸入治疗，分为两组：治疗组38例，黄芪颗粒配合常规治疗。对照组30例，常规治疗。疗程均为2周，疗程前后测肺功能。随诊1年。另设正常对照组 ,21例均为健康小儿。所有患儿在治疗前、2周后及正常对照组儿童抽血采用放射免疫分析法测定血浆ET。结果：肺功能治疗组比对照组有明显改善，两组患者ET值，两组治疗前与正常对照组比较，均P<0.01；治疗组与对照组治疗后比较，均P<0.01，但仍低于正常对照组。随访呼吸道感染发作与哮喘发作治疗组比对照组均减低。结论：黄芪颗粒配合常规治疗支气管哮喘疗效佳，复发率低，值得推广。
【关键词】黄茂颗粒；支气管哮喘；内皮素；肺功能
Astragalus Granule in treating acute asthmatic children the clinical efficacy and effect on endothelin
【Abstract】 Objective ：Astragalus particles of clinical treatment of acute asthma children before and after treatment of plasma endothelin. Methods: Development of children with acute asthma, 68 patients were given doses of the corresponding level of inhaled corticosteroid therapy, were divided into two groups: treatment group 38 cases, conventional treatment with Astragali particle. Control group of 30 patients with conventional therapy. A course of 2 weeks, lung function test before and after treatment. Followed up for 1 year. A separate control group, 21 patients were healthy children. All patients before treatment, 2 weeks after the blood sample and the control group of children determined by radioimmunoassay of plasma ET. Results: Pulmonary function in treatment group than the control group improved significantly in both groups of patients ET value, the two groups before treatment compared with control group, all P <0.01; the treatment group compared with the control group after treatment, both P <0.01, but still Lower than the control group. Follow-up episodes of respiratory tract infection and asthma attack treatment group were lower than the control group. Conclusion: Astragalus particles with good conventional treatment of bronchial asthma, low relapse rate, is worth promoting.
【Keywords 】HuangMao HT particle; The bronchus asthma; Endothelin; Lung function
【中图分类号】R425【文献标识码】B【文章编号】1005-0515(2011)03-0018-02
支气管哮喘(哮喘)是目前发病率最高的慢性疾病之一，治疗上缺乏行之有效的方法。内皮素(ET)是一种由21个氨基酸残基组成的血管活性多肽,是机体在缺血、缺氧及应激状态下产生的一种致损伤因子[1]。其中异构体 ET- 1 在肺内含量最高,并与某些心肺疾病密切相关[2] ......
您现在查看是摘要介绍页，详见PDF附件(2627kb)。