胱抑素C在临床中的运用研究(2)
 |
| 第1页 |
参见附件。
综上所述，由于CysC特定的生物特性及功能，使其成为比较理想的肾小球滤过率的标志物。但在临床实际应用中，还存在一些问题：首先是测量方法有待完善以进一步提高其准确性和精确性，第二是如何排除一些影响因素的干扰，第三CysC的价值还需要一些大规模、多中心和前瞻性的试验提供足够的数据支持。相信随着对CysC研究的深入和其本身测量方法的改进，CysC必将显示出越来越重要的临床价值，为我们更好的了解肾脏病的发病机制和早期诊断提供很好的帮助。
参考文献
[1] BARRETTAJ,FRITZH,GRUBBA,et,al,Nomenclature and classification of the proteins homologous with cysteine-proteinase inhibitor chicken cystatin[J].BiochemJ,1986,236,(1):312
[2] SAITOHE,SABATINILM,EDDYRL,et,al,The human cystatin C gene (CST3) is a member of the cystatin gene family which is localized on chromosome 20[J].Scand J Clin Lab Invest,1989,162,(3):1324-1331
[3] ABRAHAMSON M,BARRETT A J,SALVESEN G,et al,Isolation of six cysteine proteinase inhibitors from human urine.Their physicochemical and enzyme kinetic properties and concentrations in biological fluids[J]. J Biol Chem,1986,261(24):11282-9
[4] MUSSAP M.Biochemistry and clinical role of human cystatin C[J].Crit Rev Clin Lab Sci,2004,41(5-6):467-550
[5] Finney H,Newman DJ,Gruber W,et al. Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA BNⅡ)[J].Clin Chem 1977;43(6):1016-1022
[6] Kyhse-Andersen J,Schmidt C Nordin Get al.Serum cystatin C,determined by a rapid automated particle-enhanced turbidimetric method,is a better marker than serum creatinine for glomerular filtration rate[J].Clim Chem 1994;40(10):1921-1926
[7] PUCCI L,TRISCORNIA S,LUCCHESI D,et al.Cystatin C and estimates of renal function:searching for a batter measure of kidney function in diabetic patients [J].Clin Chem,2007,53(3):480-488
[8] (Risch L,Herklotz R,Blumberg A,et al.Effects of glcocorticoid immuno suppression on serum cystatin C concentrations in renal transplants ......
您现在查看是摘要介绍页，详见PDF附件(2981kb)。