肺癌患者输注PRC前后血清TNF-α\IFN-γ测定的临床意义(1)
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(1江苏连云港市中心血站 江苏 连云港 222000;
2连云港市第一人民医院 江苏 连云港 222000)
【摘要】：目的：探讨了肺癌患者输注悬浮红细胞(PRC)前后血清TNF-α、IFN-γ水平的变化及意义。方法：应用放免法和酶联法对33例肺癌患者进行了输注PRC前后血清TNF-α、IFN-γ水平的检测，并与35名正常健康人作比较。结果：肺癌患者在输注PRC前血清TNF-α、IFN-γ水平非常显著地高于正常人组(P<0.01)，经输注2周后血清TNF-α、IFN-γ水平与正常人组比较仍有差异(P<0.05)。结论：输注PRC对肺癌患者地疗效具有重要地临床价值。
【关键词】 肺癌;肿瘤坏死因子-α;干扰素
Clinical significanceofdeterminationofchanges of serumTNF-α、IFN-γlevels after
preserved red cells (PRC)transfusion in patients with lung cancer
Yuan Haitao He Haoming Li Keqin
【Abstract】Objective :To explore the changes of serumTNF-α、IFN-γlevels after preserved red cells(PRC)transfusion in patients with lung cancer .Methods: serumTNF-αlevels (with RIA)and IFN-γlevels(with ELISA)were detectedboth before and after PRC transfudion in patients with lung cancer as well as in 35 controls. Results :Before transfusion serumTNF-α、IFN-γlevels in the patients were significantly higher than those in the controls(P<0.01),after 2 weeks of PRC transfusion the serumTNF-α、IFN-γlevels though correctedmarkedly remained significantly higher than those in cintrols(P<0.05).Conclusions :Transfusion preserved red cells is effective treatment and has important role in clinical application in patients with lung cancer .
【Key words】Lung cancer;Preservedred cells (PRC ) ;Tumor necrosis factor -α (TNF-α)interferon-γ(IFN-γ)
【中图分类号】R602.46 【文献标识码】A 【文章编号】1005-0515(2011)09-0041-01
文献证实[1]：TNF-α最早发现在体内外具有显著抗肿瘤效应的细胞因子。IFN-γ在促进Th1极化过程中发挥着关键作用[2] ......
(1江苏连云港市中心血站 江苏 连云港 222000;
2连云港市第一人民医院 江苏 连云港 222000)
【摘要】：目的：探讨了肺癌患者输注悬浮红细胞(PRC)前后血清TNF-α、IFN-γ水平的变化及意义。方法：应用放免法和酶联法对33例肺癌患者进行了输注PRC前后血清TNF-α、IFN-γ水平的检测，并与35名正常健康人作比较。结果：肺癌患者在输注PRC前血清TNF-α、IFN-γ水平非常显著地高于正常人组(P<0.01)，经输注2周后血清TNF-α、IFN-γ水平与正常人组比较仍有差异(P<0.05)。结论：输注PRC对肺癌患者地疗效具有重要地临床价值。
【关键词】 肺癌;肿瘤坏死因子-α;干扰素
Clinical significanceofdeterminationofchanges of serumTNF-α、IFN-γlevels after
preserved red cells (PRC)transfusion in patients with lung cancer
Yuan Haitao He Haoming Li Keqin
【Abstract】Objective :To explore the changes of serumTNF-α、IFN-γlevels after preserved red cells(PRC)transfusion in patients with lung cancer .Methods: serumTNF-αlevels (with RIA)and IFN-γlevels(with ELISA)were detectedboth before and after PRC transfudion in patients with lung cancer as well as in 35 controls. Results :Before transfusion serumTNF-α、IFN-γlevels in the patients were significantly higher than those in the controls(P<0.01),after 2 weeks of PRC transfusion the serumTNF-α、IFN-γlevels though correctedmarkedly remained significantly higher than those in cintrols(P<0.05).Conclusions :Transfusion preserved red cells is effective treatment and has important role in clinical application in patients with lung cancer .
【Key words】Lung cancer;Preservedred cells (PRC ) ;Tumor necrosis factor -α (TNF-α)interferon-γ(IFN-γ)
【中图分类号】R602.46 【文献标识码】A 【文章编号】1005-0515(2011)09-0041-01
文献证实[1]：TNF-α最早发现在体内外具有显著抗肿瘤效应的细胞因子。IFN-γ在促进Th1极化过程中发挥着关键作用[2] ......
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