【摘要】 目的 比较思瑞康与氯丙嗪对首发精神分裂症患者认知功能的影响。方法 将符合CCMD-3诊断标准的首发精神分裂症患者60例随机分为两组，分别给予思瑞康与氯丙嗪治疗8周。分别于入组前及治疗8周末，测查威斯康星卡片分类试验(WCST)、数字划销试验(CT)、韦氏成人智力测验(WAIS-RC)。结果 治疗后思瑞康组的WAIS、CT、WCST等成绩明显好于氯丙嗪组。结论 思瑞康对首发精神分裂症患者的认知改善优于氯丙嗪。

    【关键词】 首发精神分裂症；认知功能；思瑞康；氯丙嗪

    A Comparison of Cognitive Founction in First Episode Schizophrenia Treated with Seroquel or Chlorpromazine. Ning Zhengyuan, Liu Shuping, Jin Shijun. Hebei Mental Health Center, Baoding 071000, P.R.China

    【Abstract】 Objective To compare the effecacy of seroquel with chlorpromazine on cognitive function in first episode schizophrenia patients. Methods Sixty patients with first episode schizophrenia were randomly divided into two groups, treated with seroquel or chlorpromazine for 8 weeks, patients were tested with the Wisconsin Card Sort Test(WCST), the Cancellation Test(CT), the Wechsler adult intelligence scale(WAIS). Results The group of seroquel is significantly better than chlorpromazine in WAIS ......