慢性阻塞性肺疾病急性加重期检测血清C反应蛋白的临床意义(1)
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【中图分类号】R563【文献标识码】A【文章编号】1005-2720(2009)04-0157-02
【摘要】目的：慢性阻塞性肺病(COPD)患者急性加重期与缓解期血、晨痰C反应蛋白(CRP)浓度的变化以及肺功能损害程度与CRP浓度变化的关系。方法：选择COPD患者60例，进行肺功能第1秒用力呼气容量(FEV1)和一秒率(FEV1/FVC)测定；收集患者晨痰及同期静脉血，采用ELISA法检测CRP浓度。同时，选择30例健康者作为对照组进行CRP测定。结果：患者急性加重期血、晨痰CRP含量分别高达(28.37±9.35)、(29.68±8.41)mg/L，而缓解期迅速下降至(6.28±2.16)、(12.42±5.53)mg/L，较急性加重期显著降低(P均<0.01)。COPD患者肺功能FEV1变化与血、晨痰CRP浓度变化呈负相关(分别为r=-0.856和r=-0.527，P均<0.001)；患者肺功能FEV1/FVC变化与血、晨痰CRP浓度变化呈负相关(分别为r=-0.576，和r=-0.753，P均<0.05)。结论：CRP浓度的增高可能与肺功能损害程度有关。
【关键词】慢性阻塞性肺疾病；C反应蛋白；肺功能
The clinical significance of C-reactive proteins in acute exacerbation of chronic obstruction pulmonary disease.Tan Yingqiang.(People’s hospital of Taishan city，Guangdong 529200，China)
【Abstract】Objective：To investigate the changes of C-reactive protein(CRP)level in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and stable chronic obstruction pulmonary disease(COPD)，and to analyze the correlation between the lung function and CRP levels.Methods：Sputum and serum specimens were obtained from 60 COPD patients diagnosed according to the national criteria.The CRP level was measured by enzyme-linked immunosorbent assays.The lung function indexes such as the forced expiratory volume in one second(FEV1)and the forced expiratory volume in one second/forced vital capacity(FEV1/FVC) were also determined.Results：The serum CRP levels of COPD patients at exacerbation(28.37±9.35)，(29.68±8.41)mg/L were significantly higher than those of the patients at stable(6.28±2.16)，(12.42±5.53)mg/L(P<0.01).The correlations between changes of serum CRP levels and FEV1，were negative(r=-0.856，r=-0.527，respectively，P<0.001).And the correlations between changes of serum and sputum CRP levels and FEV1/FVC were negative(r=-0.576，r=-0.753，respectively，P<0.05).Conclusion：The damage of lung function in COPD patients is associated with the increase of CRP level.
【Key Words】Chronic obstructive pulmonary disease；C-reactive protein；Lung function
慢性阻塞性肺病(chronic obstructive pulmonary disease ......
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