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妊娠合并甲状腺功能亢进37例临床分析(1)
http://www.100md.com 2009年4月15日 曲珍华 郭晓铃 范 联 周 杏
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     【中图分类号】R714.256【文献标识码】A【文章编号】1005-2720(2009)08-0290-03

    【摘要】目的:探讨甲状腺功能亢进症(甲亢)患者妊娠期治疗是否能减少妊娠并发症及改善母婴结局。方法:回顾分析2006年1月~2008年8月3年间在我院分娩的37例妊娠合并甲亢患者妊娠期治疗及母婴结局。37例患者分二组:病情控制满意组(A组):24例患者,在孕前或孕中诊断、系统治疗,病情控制满意,分娩时甲状腺功能正常。病情控制不满意组(B组):13例患者,孕前或孕中诊断甲亢,孕期未系统治疗或就诊晚,病情重,终止妊娠时甲状腺功能仍明显异常。结果:妊娠合并甲亢进入围产期的发病率为2.74‰(37/13516),B组与A组相比,重度子痫前期(23.1%和12.5%)、胎膜早破(23.0%和12.5%)、羊水异常(8.3%和0%)、早产(69.2%和8.3%)、低体重儿(61.5%和4.2%)、新生儿畸形(15.4%和0%)、围产儿死亡(15.4%和0%)的发生率明显增加。结论:甲亢的孕前和孕期治疗、积极控制病情,可有效降低孕期并发症,改善围产期母儿结局。

    【关键词】甲状腺功能亢进症;母儿并发症;妊娠结局

    The clinical analysis on 37 gravidas who were hyperthyreosis.Qu Zhenhua,Guo Xiaoling,Fan Lian,Zhou Xing.(The maternal and child health care hospital of Foshan,Guangdong 528000 China)

    【Abstract】Objective:To investigate the influences of the treatment on hyperthyroidism during gestational period.Methods:Analyzed the treatment and the outcome of peripartum of pregnancy complicated hyperthyroidism retrospectively during January 2006 to August 2008.There were 37 patients who were diagnosed as hyperthyroidism in the period of progestation or duration of pregnancy were divided to two groups,group A and group B.Group A who were consist of 24 patients were treated systematically,meanwhile,group B who were consist of 13 patients was not.The controlation on pathogenetic condition of group A was satisfaction,and euthyroidism was normal when delivery,when group B was opposite.Results:The incidence rate of pregnancy complicated hyperthyroidism in peripartum is 2.74‰ in peripartum.The comparison of group B and group A,the incidences of severe eclampsism(23.1% and 12.5%),premature rupture of membrane(23.0% and 12.5%),abnormity of amniotic fluid(8.3% and 0%),prematurity(69.2% and 8.3%),low birth weight infant(61.5% and 4.2%),neonate malformation(15.4% and 0%),the death of perinatal child(15.4% and 0%)were increasing obviously.Conclusion:The treatment on hyperthyroidism in the period of progestation and duration of pregnancy,and the controling on pathogenetic condition activly,could reduce complication of gestation and improve the outcome of peripartum.

    【Key Words】Hyperthyroidism;Gestational period complication;Pregnancy fate ......

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