昂丹司琼与长托宁单次注射用于预防腹腔镜胆囊切除术后恶心呕吐的对比研究(1)
 |
| 第1页 |
参见附件(1510KB，2页)。
【中图分类号】R971【文献标识码】A【文章编号】1005-2720(2009)15-0555-02
【摘要】目的：观察单次注射昂丹司琼、长托宁对预防腹腔镜下胆囊切除术后患者恶心呕吐的作用。方法：选择45例择期腹腔镜胆囊切除手术患者，ASA分级Ⅰ~Ⅱ级，随机分为3组，每组15例，在麻醉诱导前10min分别静脉注射昂丹司琼4mg(A组)、长托宁1mg(B组)、生理盐水10ml(C组)；对比分析3组患者手术结束后24h内恶心呕吐发生率。结果：3组患者中C组术后恶心呕吐的发生率最高，与A、B组比较差异有统计学意义(P<0.05)；A组与B组发生率相近(P>0.05)。结论：昂丹司琼与长托宁单次注射用药均能明显减少腹腔镜胆囊切除术后患者恶心呕吐的发生率。
【关键词】胆囊切除术；术后恶心呕吐；昂丹司琼；长托宁
Comparison on incidence of postoperative nausea and vomiting induced by single injection of ondansetron and penehyclidine in cases with laparoscopic cholecystectomy.Ni Haoyun，Xie Hong，Yang Jin，Tan Min.(The asffiliated Xiangyue hospital of Hunan institute of parasitic diseases，Hunan 414000，China)
【Abstract】Objective：To observe the incidence of postoperative nausea and vomiting induced by single injection of ondansetron and penehyclidine in cases with laparoscopic cholecystectomy.Methods：45 laparoscopic cholecystectomized cases with Ⅰand Ⅱscale of ASA were randomly distributed into three groups.There were 15 cases in each group and they were injected by 4mg of ondansetron hydrochloride (group A)， 1mg of penehyclidine hydrochloride (group B)，and 10ml of physiologic saline (group C)，respectively，10 minutes prior to anaesthesia induction.Incidence of postoperative nausea and vomiting 24 hours after operations were compared among three groups.Results：Groups C had the highest incidence of postoperative nausea and vomiting.There were significant differences in the incidence of postoperative nausea and vomiting between group C and group A (P<0.05)，and group C and group B (P<0.05).Yet there was no significant differences between group A and group B (P>0.05).Conclusion：Ondansetron and penehyclidine can reduce the incidence of postoperative nausea and vomiting in cases with laparoscopic cholecystectomy.
【Key Words】Cholecystectomy；Postoperative nausea and vomiting；Ondansetron；Penehyclidine
尽管麻醉药品不断更新和麻醉技术也在进展，术后恶心呕吐(postoperative nausea and vomiting，PONV)仍然是常见的术后并发症，据报道平均发生率为20%~30%[1]。腹腔镜手术后PONV发生率更高，术后8h内PONV发生率高达73.9%，8~24h内仍达60.8%[2]。PONV增加了病人的痛苦，严重者可引起较严重的并发症，如伤口裂开、出血、吸入性肺炎、颅内压升高、水电解质紊乱等 ......
您现在查看是摘要介绍页，详见PDF附件(1510KB，2页)。