基于证-症-方药网络的中医治疗阻塞性睡眠呼吸暂停低通气综合征用药规律研究(1)
摘要：目的 探討中医治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)用药配伍规律，为临床诊疗提供参考。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(维普网)建库至2018年5月收录的中医治疗OSAHS文献，采用Cytoscape2.8构建证-症-方药数据网络，采用IBM SPSS Modeler 14.2关联规则算法进行组方规律挖掘，熵层次聚类分析挖掘潜在的新方组合。结果 OSAHS证候以肺肾气虚证、痰热壅肺证、脾肾阳虚证、气虚血瘀证、痰瘀互结证等为主，症状以打鼾、痰响、咳喘、胸闷气短、夜寐不安、多汗、呼吸困难、嗜睡、神疲乏力、发热、心悸等呼吸系统及神经系统症状为主。共纳入处方371首，涉及药物255味，总频次3821次，高频药物有茯苓、黄芪、丹参、白术等，得到新方组合11个。核心药物组合主要由具有补肺肾之气、化痰止咳、温阳利水、泻肺平喘、活血化瘀、宽胸散结等功效的药物组成。结论 中医治疗OSAHS以补虚祛实为原则，采用补虚、化痰止咳、利水、活血等治法进行组方配伍。
关键词：阻塞性睡眠呼吸暂停低通气综合征;证候;症状;关联规则;熵层次聚类;数据挖掘
中图分类号：R2-05;R256.9 文献标识码：A 文章编号：1005-5304(2019)09-0094-05
Study on Medication Rules of TCM Treatment for Obstructive Sleep Apnea-hypopnea Syndrome Based on Syndrome-symptom-prescription Network
GU Zhirong1， MA Tianxiang2， SU Xiaoyan3， XU Aixia1， QI Mei1， LI Fang2， GE Bin1
1. Department of Pharmacy， Gansu Provincial People's Hospital， Lanzhou 730000， China;2. College of Pharmacy， Gansu University of Chinese Medicine， Lanzhou 730000， China;3. Sleep Center， Gansu Provincial People's Hospital， Lanzhou 730000， China
Abstract： Objective To explore the medication rules and compatibility of TCM treatment for obstructive sleep apnea-hypopnea syndrome (OSAHS); To provide references for clinical diagnosis and treatment. Methods Literature about TCM treatment for OSAHS was searched in CNKI， CBM， VIP and Wanfang Data from the establishment to May 2018. Cytoscape2.8 was used to construct syndrome-symptom-prescription network. The IBM SPSS Modeler 14.2 association rule algorithm was used to perform medication rule mining， and entropy hierarchical cluster analysis was used to mine potential new medicinal combinations. Results The syndromes of OSAHS weremainly lung-kidney qi deficiency， phlegm-heat obstructing lung， spleen-kidney yang deficiency， qi deficiency and blood stasis， and turbid phlegm and blood stasis， etc. The symptoms of OSAHS were mainly respiratory and neurological symptoms of snoring， phlegm sound， cough， chest distress and shortness of breath， restless sleep， excessive sweating， difficulty breathing， drowsiness， fatigue， fever， and palpitations， etc. A total of 371 prescriptions for the treatment of OSAHSwere included， covering 255 kinds of Chinese materia medica， with the frequency of 3821 times. The medicines with high frequency were Poria， Astragali Radix， Salviae Miltiorrhizae et Rhizoma， and Astractylodis Macrocephalae Rhizoma. 11 new medicinal combinations were obtained. The core combinations mainly consisted of Chinese materia medica with the efficacy of tonifying lung-kidney qi， clearing phlegm and relieving coughing， warming yang to promote diuresis， removing heat from the lung and relieving asthma， promoting blood circulation and removing stasis， and relieving chest stiffness to dissipate mass， etc. Conclusion TCM treatment for OSAHS is based on the principle of tonifying deficiency and dispelling excess， and the prescriptions and compatibility mainly use the methods of tonifying deficiency， resolving phlegm and relieving coughing， promoting diuresis， and promoting blood circulation., 百拇医药(顾志荣 马天翔 苏晓艳 许爱霞 祁梅 李芳 葛斌)
关键词：阻塞性睡眠呼吸暂停低通气综合征;证候;症状;关联规则;熵层次聚类;数据挖掘
中图分类号：R2-05;R256.9 文献标识码：A 文章编号：1005-5304(2019)09-0094-05
Study on Medication Rules of TCM Treatment for Obstructive Sleep Apnea-hypopnea Syndrome Based on Syndrome-symptom-prescription Network
GU Zhirong1， MA Tianxiang2， SU Xiaoyan3， XU Aixia1， QI Mei1， LI Fang2， GE Bin1
1. Department of Pharmacy， Gansu Provincial People's Hospital， Lanzhou 730000， China;2. College of Pharmacy， Gansu University of Chinese Medicine， Lanzhou 730000， China;3. Sleep Center， Gansu Provincial People's Hospital， Lanzhou 730000， China
Abstract： Objective To explore the medication rules and compatibility of TCM treatment for obstructive sleep apnea-hypopnea syndrome (OSAHS); To provide references for clinical diagnosis and treatment. Methods Literature about TCM treatment for OSAHS was searched in CNKI， CBM， VIP and Wanfang Data from the establishment to May 2018. Cytoscape2.8 was used to construct syndrome-symptom-prescription network. The IBM SPSS Modeler 14.2 association rule algorithm was used to perform medication rule mining， and entropy hierarchical cluster analysis was used to mine potential new medicinal combinations. Results The syndromes of OSAHS weremainly lung-kidney qi deficiency， phlegm-heat obstructing lung， spleen-kidney yang deficiency， qi deficiency and blood stasis， and turbid phlegm and blood stasis， etc. The symptoms of OSAHS were mainly respiratory and neurological symptoms of snoring， phlegm sound， cough， chest distress and shortness of breath， restless sleep， excessive sweating， difficulty breathing， drowsiness， fatigue， fever， and palpitations， etc. A total of 371 prescriptions for the treatment of OSAHSwere included， covering 255 kinds of Chinese materia medica， with the frequency of 3821 times. The medicines with high frequency were Poria， Astragali Radix， Salviae Miltiorrhizae et Rhizoma， and Astractylodis Macrocephalae Rhizoma. 11 new medicinal combinations were obtained. The core combinations mainly consisted of Chinese materia medica with the efficacy of tonifying lung-kidney qi， clearing phlegm and relieving coughing， warming yang to promote diuresis， removing heat from the lung and relieving asthma， promoting blood circulation and removing stasis， and relieving chest stiffness to dissipate mass， etc. Conclusion TCM treatment for OSAHS is based on the principle of tonifying deficiency and dispelling excess， and the prescriptions and compatibility mainly use the methods of tonifying deficiency， resolving phlegm and relieving coughing， promoting diuresis， and promoting blood circulation., 百拇医药(顾志荣 马天翔 苏晓艳 许爱霞 祁梅 李芳 葛斌)