mRNA in the transfection BMSCs was increased by RT-qPCR， and there was statistical significance between the normal BMSCs and no-load BMSCs (P<0.05). Compared with tumorigenic group and no-load group， the tumor mass and tumor weight of the transfection group， the medicine group and the combination group increased little (P<0.05); Compared with the transfection group and the medicine group ......