compound for prevention and treatment of CAG. Methods Totally 120 SPF Wistar rats were randomly divided into blank group and model group. CAG animal models were reproduced by comprehensive method. The model rats were randomly divided into model group， vitacoenzyme tablets group and Xiangsha Liujunzi Decoction high-， medium- and low-dosage groups. The blank group and model group were given 10 mL/(kg·d) distilled water for gavage， and Xiangsha Liujunzi Decoction high-， medium- and low-dosage groups were given 24 g/(kg d)， 12 g/(kg d)， and 6 g/(kg·d) Xiangsha Liujunzi Decoction， respectively， for gavage. Vitacoenzyme tablets group was given 0.30 g / (kg·d) vitacoenzyme tablets， for consecutive 120 d. The content of VEGF in gastric tissue was detected by ELISA， and the gene and protein expressions of PI3K， PTEN and AKT were detected by RT-PCR and Western blot， respectively. Results Compared with the blank group， the general survival condition of the model group was worse; the gastric mucosa of the model group was thinner， the arrangement of epithelial cells and glands was disordered and sparse， the number of glands was significantly reduced， the muscular layer of the mucosa was thicker and extended to the lamina propria， a large number of inflammatory infiltration could be seen， PTEN gene and protein expression in gastric tissue were significantly reduced (P<0.01)， and the content of VEGF and the gene and protein expressions of AKT and PI3K in gastric tissues significantly increased (P<0.01). Compared with model group， the gene expression PTEN in gastric tissue of rats in Xiangsha Liujunzi Decoction high-dosage group was significantly higher (P<0.01)， and the content of VEGF and gene and protein expressions of AKT and PI3K in gastric tissues significantly decreased (P<0.01). Conclusion Xiangsha Liujunzi Decoction can exert the therapeutic effect on CAG by improving the general survival of the model rats and the pathological state of gastric mucosa， up-regulating the expression of PTEN in gastric tissue， down-regulating the expression of VEGF， AKT and PI3K., 百拇医药(段永强 巩子汉 王丽园 成映霞 王强 杨晓轶 李兰珍 段云燕)