黄连-大黄-肉桂复方及其组分对人肝癌SMMC-7721及HepG2细胞增殖的影响(5)
[10] NG L T, WU S J. Antiproliferative activity of cinnamomum cassia constituents and effects of pifithrin-alpha on their apoptotic signaling pathways in HepG2 cells[J]. Evid Based Complement Alternat Med,2011,2011:492148.
[11] 李冀,付殷,高彦宇.中药有效组分配伍研究新进展[J].中医药信息, 2014,31(3):162-164.
[12] 隋峰,张畅斌,杜新亮,等.寒热性中药的成分对TRPV1通道蛋白功能的影响[J].中药药理与临床,2009,25(5):18-20.
[13] 苟微,管冬元,方肇勤,等.小檗碱等7味中药有效成分药性的检测[J].时珍国医国药,2011,22(11):2717-2719.
[14] SPANGLE J M, ROBERTS T M, ZHAO J J. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer[J]. Biochim Biophys Acta Rev Cancer,2017,1868(1):123-131.
[15] DONG P, KONNO Y, WATARI H, et al. The impact of microRNA- mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer[J]. J Transl Med,2014, 12:231.
[16] HAFSI S, PEZZINO F M, CANDIDO S, et al. Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance[J]. Int J Oncol,2012,40(3):639-644.
[17] LIU Y, AO X, DING W, et al. Critical role of FOXO3a in carcinogenesis[J]. Mol Cancer,2018,17(1):104.
[18] FARHAN M, WANG H, GAUR U, et al. FOXO signaling pathways as therapeutic targets in cancer[J]. Int J Biol Sci,2017,13(7):815-827.
(收稿日期:2019-09-25)
(修回日期:2019-10-15;編辑:华强)
基金项目:国家自然科学基金(81503481);上海中医药大学中医基础理论学科能力提升项目(A1-Z193020110)
通讯作者:刘小美,E-mail:wfjlxm2005@126.com, http://www.100md.com(钱杨杨 吴中华 张静 潘志强 刘小美)
[11] 李冀,付殷,高彦宇.中药有效组分配伍研究新进展[J].中医药信息, 2014,31(3):162-164.
[12] 隋峰,张畅斌,杜新亮,等.寒热性中药的成分对TRPV1通道蛋白功能的影响[J].中药药理与临床,2009,25(5):18-20.
[13] 苟微,管冬元,方肇勤,等.小檗碱等7味中药有效成分药性的检测[J].时珍国医国药,2011,22(11):2717-2719.
[14] SPANGLE J M, ROBERTS T M, ZHAO J J. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer[J]. Biochim Biophys Acta Rev Cancer,2017,1868(1):123-131.
[15] DONG P, KONNO Y, WATARI H, et al. The impact of microRNA- mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer[J]. J Transl Med,2014, 12:231.
[16] HAFSI S, PEZZINO F M, CANDIDO S, et al. Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance[J]. Int J Oncol,2012,40(3):639-644.
[17] LIU Y, AO X, DING W, et al. Critical role of FOXO3a in carcinogenesis[J]. Mol Cancer,2018,17(1):104.
[18] FARHAN M, WANG H, GAUR U, et al. FOXO signaling pathways as therapeutic targets in cancer[J]. Int J Biol Sci,2017,13(7):815-827.
(收稿日期:2019-09-25)
(修回日期:2019-10-15;編辑:华强)
基金项目:国家自然科学基金(81503481);上海中医药大学中医基础理论学科能力提升项目(A1-Z193020110)
通讯作者:刘小美,E-mail:wfjlxm2005@126.com, http://www.100md.com(钱杨杨 吴中华 张静 潘志强 刘小美)