非酒精性脂肪肝的患病率及与代谢综合征关系的研究(1)
【摘要】 目的 调查非酒精性脂肪肝(NAFL)的患病率及其与代谢综合征(MS)的关系。方法 对来江苏省太湖干部疗养院健康体检的人群进行体格、血生化和B超检查。结果 共有7 156例资料齐全者进入该次调查,经超声检出NAFL 1 471例,患病率为20.6%,并随机抽取1 483例经超声检查无脂肪肝者为对照组。男、女性NAFL患病率均随年龄增加而增加(P<0.05),各年龄组男性患病率均高于女性(P<0.01)。NAFL组收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、空腹血糖(FBG)、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转移酶(GGT)均高于对照组(P<0.01),高密度脂蛋白胆固醇(HDL-C)低于对照组(P<0.01)。NAFL组合并肥胖、高血压、血糖异常、血脂异常和代谢综合征的患病率分别是76.4%、43.3%、34.2%、58.4%、42.1%,均高于对照组(P<0.01)。以NAFL取代MS 5个组分中的任何一个后,与原诊断定义相比一致性均很高(Kappa值均>0.6,P<0.001)。结论 NAFL的患病率随年龄增加而增加,且男性患病率高于女性。NAFL与MS关系密切,NAFL可以作为MS组成成分之一。
, http://www.100md.com
【关键词】 非酒精性脂肪肝;患病率;代谢综合征
【Abstract】 ObjectiveTo investigate the prevalence of nonalcoholic fatty liver(NAFL)and the association between nonalcoholic fatty liver and metabolic syndrome(MS).MethodsPeople from cadre sanatorium of Taihu in Jiangsu Province were received physical examination,blood biochemistry and type-B ultrasonic.Results A total of7 156 individuals with complete information were enrolled in the survey.1 471 cases were diagnosed as NAFL with type-B ultrasonic,the prevalence rate was 20.6%.1 483 cases who
, 百拇医药
were healthy without fatty liver confirmed with type-B ultrasonic were randomly selected and served as control group.The prevalence rate of NAFL was increased with age in both males and females(P<0.05),and was significantly higher in males than in females in each age groups(P<0.01).The level of systolic pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),fasting plasma glucose(FBG),trigalloyl glycerol(TG),cholesterol(TC),low density lipoprotein cholestorol(LDL-C),uric acid(UA),glutamate pyruvate transaminase(ALT),glutamic-oxal(o)acetic transaminase(AST)and gamma-glutamyltransferase(GGT)in the NAFL group were significantly higher than those in the control group(P<0.01),but the level of high density lipoprotein cholesferol(HDL-C)was significantly lower than those in the control group(P<0.01).The prevalence of obesity,hypertension,hyperglycemia,dyslipidemia and metabolic syndrome in the NAFL groups were 76.4%,43.3%,34.2%,58.4% and 42.1% respectively,significantly higher than those in the control group(P<0.01).There was high consistency of MS definitions before and after any component of MS was replaced by NAFL(all Kappa value>0.6,P<0.001).Conclusion The prevalence rate of NAFL is increased with age,which was significantly higher in males than that in females in each age group.NAFL is closely related with MS.NAFL may be considerd as another component of MS.
, 百拇医药
【Key words】Nonalcoholic Fatty Liver;Prevalence;Metabolic Syndrome
随着人们生活水平的提高及生活方式的改变,特别是体力活动不足,饮食结构不合理,非酒精性脂肪肝(NAFL)的发病率呈逐年上升、发病年龄年轻化的趋势。NAFL已成为我国常见的慢性肝病之一[1]。有研究表明,NAFL与代谢综合征(MS)关系密切,脂肪肝为其组分之一[2]。本研究通过对来我院健康体检的7 156名体检者的体检资料进行分析,探讨NAFL的患病率及与MS的关系。
1对象与方法
1.1对象选择2008年10月～2009年6月来我院健康体检者,共7 156例。选取经超声诊断为脂肪肝且无饮酒史或折合酒精量每周<40 g,除外病毒性肝炎、药物性肝病、肝豆状核变性、全胃肠外营养和自身免疫性疾病者,为NAFL组;并在该资料中随机抽取经超声检查无脂肪肝的体检者为对照组。
1.2方法使用统一设计的表格,由培训合格的医师进行询问,填写一般情况、既往病史、烟酒嗜好等。固定一名专职B超医师行肝胆超声检查,出具统一的诊断报告。测量全部调查对象的血压、身高、体重,计算体重指数(BMI)。应用酶法测定全部调查对象的空腹血糖(FPG)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转移酶(GGT)。, 百拇医药(王 凌 沈振海 徐 勤 陆 昀)
, http://www.100md.com
【关键词】 非酒精性脂肪肝;患病率;代谢综合征
【Abstract】 ObjectiveTo investigate the prevalence of nonalcoholic fatty liver(NAFL)and the association between nonalcoholic fatty liver and metabolic syndrome(MS).MethodsPeople from cadre sanatorium of Taihu in Jiangsu Province were received physical examination,blood biochemistry and type-B ultrasonic.Results A total of7 156 individuals with complete information were enrolled in the survey.1 471 cases were diagnosed as NAFL with type-B ultrasonic,the prevalence rate was 20.6%.1 483 cases who
, 百拇医药
were healthy without fatty liver confirmed with type-B ultrasonic were randomly selected and served as control group.The prevalence rate of NAFL was increased with age in both males and females(P<0.05),and was significantly higher in males than in females in each age groups(P<0.01).The level of systolic pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),fasting plasma glucose(FBG),trigalloyl glycerol(TG),cholesterol(TC),low density lipoprotein cholestorol(LDL-C),uric acid(UA),glutamate pyruvate transaminase(ALT),glutamic-oxal(o)acetic transaminase(AST)and gamma-glutamyltransferase(GGT)in the NAFL group were significantly higher than those in the control group(P<0.01),but the level of high density lipoprotein cholesferol(HDL-C)was significantly lower than those in the control group(P<0.01).The prevalence of obesity,hypertension,hyperglycemia,dyslipidemia and metabolic syndrome in the NAFL groups were 76.4%,43.3%,34.2%,58.4% and 42.1% respectively,significantly higher than those in the control group(P<0.01).There was high consistency of MS definitions before and after any component of MS was replaced by NAFL(all Kappa value>0.6,P<0.001).Conclusion The prevalence rate of NAFL is increased with age,which was significantly higher in males than that in females in each age group.NAFL is closely related with MS.NAFL may be considerd as another component of MS.
, 百拇医药
【Key words】Nonalcoholic Fatty Liver;Prevalence;Metabolic Syndrome
随着人们生活水平的提高及生活方式的改变,特别是体力活动不足,饮食结构不合理,非酒精性脂肪肝(NAFL)的发病率呈逐年上升、发病年龄年轻化的趋势。NAFL已成为我国常见的慢性肝病之一[1]。有研究表明,NAFL与代谢综合征(MS)关系密切,脂肪肝为其组分之一[2]。本研究通过对来我院健康体检的7 156名体检者的体检资料进行分析,探讨NAFL的患病率及与MS的关系。
1对象与方法
1.1对象选择2008年10月～2009年6月来我院健康体检者,共7 156例。选取经超声诊断为脂肪肝且无饮酒史或折合酒精量每周<40 g,除外病毒性肝炎、药物性肝病、肝豆状核变性、全胃肠外营养和自身免疫性疾病者,为NAFL组;并在该资料中随机抽取经超声检查无脂肪肝的体检者为对照组。
1.2方法使用统一设计的表格,由培训合格的医师进行询问,填写一般情况、既往病史、烟酒嗜好等。固定一名专职B超医师行肝胆超声检查,出具统一的诊断报告。测量全部调查对象的血压、身高、体重,计算体重指数(BMI)。应用酶法测定全部调查对象的空腹血糖(FPG)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转移酶(GGT)。, 百拇医药(王 凌 沈振海 徐 勤 陆 昀)