摘 要 内分泌治疗用于乳腺癌已有100多年的历史，具有疗效确实、耐受性良好的特点，已在各期激素受体阳性乳腺癌的辅助治疗中占据重要地位。目前，三苯氧胺仍是绝经前患者的标准用药，绝经后患者则首选芳香化酶抑制剂。本文就近年来进行的多个大宗临床试验，对乳腺癌内分泌治疗研究进展做一综述。

    关键词 乳腺癌 内分泌治疗 三苯氧胺 芳香化酶抑制剂

    中图分类号：R737.9 文献标识码：C 文章编号：1006-1533(2012)18-0009-05

    The research progress in the endocrine treatment of breast cancer

    ZHU Yue-ming, LI Dan, WU Xue-yong

    (Cancer Department of Jinan District Central Hospital, Shanghai 200040, China)

    ABSTRACT Endocrine therapy has been used to treat breast cancer for more than 100 years, which has the features of reliable treatment effect and good tolerance and has occupied an important position in adjuvant therapy of various periods of hormone receptor-positive breast cancer. At present, tamoxifen is still the standard medication for the pre-menopausal patients, while aromatase inhibitors are recommended for the postmenopausal patients. This article reviews the research progress in the endocrine treatment of breast cancer based on carrying out the multiple bulk of clinical trials recent years. ......