急性肾功能衰竭患者外周血白细胞计数和血小板参数值的变化及临床意义(1)
摘 要 目的：探讨急性肾功能衰竭(acute renal failure， ARF)患者外周血白细胞(white blood cell， WBC)计数和血小板(platelet， PLT)参数值的变化及临床意义。方法：选取67例ARF患者(观察组)和65例慢性肾炎患者(对照组)作为研究对象，采用全自动血细胞分析方法检测患者的外周血WBC计数和PLT参数值，包括PLT计数、平均PLT体积(mean platelet volume， MPV)、PLT体积宽度分布(platelet volume distribution width， PDW)、PLT压积(thrombocytocrit， PCT)和红细胞分布宽度(red cell distribution width， RDW)，同时按照《有关急性肾损伤的肾病改善综合结果》(Kidney Disease Improvement Global Outcomes for Acute Kidney Injury)中的疾病分期标准评估患者的病情严重程度。结果：观察组患者的外周血WBC计数显著高于对照组患者(P<0.05)，PLT计数、MPV、PDW和PCT均显著低于对照组患者(P均<0.05)，但两组患者RDW的差异无统计学意义；ARFⅠ期患者的外周血WBC计数、PLT计数、MPV、PDW、PCT均显著好于Ⅱ、Ⅲ期患者(P均<0.05)，Ⅱ期患者的外周血WBC计数、PLT计数、MPV、PDW、PCT均显著好于Ⅲ期患者(P均<0.05)；ARF患者的死亡率为14.93%、感染率为77.61%、出血率为26.87%，其中无并发症患者的外周血WBC计数、PLT计数、MPV、PDW和PCT均显著好于有并发症的患者(P均<0.05)。结论：检测外周血WBC计数和PLT参数值的变化对ARF患者的病情严重程度和预后评估具有重要的临床意义。
, 百拇医药
关键词 急性肾功能衰竭 白细胞计数 血小板参数
中图分类号：R692.5； R446.11 文献标识码：B 文章编号：1006-1533(2014)19-0046-04
Changes of peripheral white blood cell count and platelet parameters in patients
with acute renal failure and their clinical significance*
Liu Xilong**， Xie Linying， He Zhihong
(Department of Laboratory， People’s Hospital of Yichun City， Jiangxi 336000， China)
, 百拇医药
Abstract Objective： To study the changes of peripheral white blood cell (WBC) count and platelet (PLT) parameters in patients with acute renal failure (ARF) and their clinical significance. Methods： Sixty-seven patients with ARF were selected as an observation group and 65 cases of normal subjects as a control group， and peripheral WBC count and PLT parameters such as mean PLT volume (MPV)， PLT volume distribution width (PDW)， thrombocytocrit (PCT)， and red cell distribution width (RDW) were detected by an automatic blood cell analysis method and ARF severity of patients were assessed by disease staging criteria in Kidney Disease Improvement Global Outcomes for Acute Kidney Injury. Results： Peripheral WBC count was significantly higher while PLT， MPV， PDW and PCT were significantly lower in the observation group than in the control group (P<0.05)， however， the difference of RDW between two groups was not significant. Peripheral WBC count， PLT， MPV， PDW， and PCT were obviously better in patients with stage I than with stage II， III and all the indexes were better in patients with stage II than with the stage III (P<0.05). Mortality accounted for 14.93%， infection rate 77.61% and bleeding rate 26.87% in the patients with ARF. Peripheral WBC count， PLT， MPV， PDW， and PCT were better in patients without complications than with complications (P<0.05). Conclusion： Detection of peripheral WBC count and PLT parameters play an important role in evaluation of the severity and prognosis of ARF., http://www.100md.com(刘喜龙 谢琳瑛 何志红)
, 百拇医药
关键词 急性肾功能衰竭 白细胞计数 血小板参数
中图分类号：R692.5； R446.11 文献标识码：B 文章编号：1006-1533(2014)19-0046-04
Changes of peripheral white blood cell count and platelet parameters in patients
with acute renal failure and their clinical significance*
Liu Xilong**， Xie Linying， He Zhihong
(Department of Laboratory， People’s Hospital of Yichun City， Jiangxi 336000， China)
, 百拇医药
Abstract Objective： To study the changes of peripheral white blood cell (WBC) count and platelet (PLT) parameters in patients with acute renal failure (ARF) and their clinical significance. Methods： Sixty-seven patients with ARF were selected as an observation group and 65 cases of normal subjects as a control group， and peripheral WBC count and PLT parameters such as mean PLT volume (MPV)， PLT volume distribution width (PDW)， thrombocytocrit (PCT)， and red cell distribution width (RDW) were detected by an automatic blood cell analysis method and ARF severity of patients were assessed by disease staging criteria in Kidney Disease Improvement Global Outcomes for Acute Kidney Injury. Results： Peripheral WBC count was significantly higher while PLT， MPV， PDW and PCT were significantly lower in the observation group than in the control group (P<0.05)， however， the difference of RDW between two groups was not significant. Peripheral WBC count， PLT， MPV， PDW， and PCT were obviously better in patients with stage I than with stage II， III and all the indexes were better in patients with stage II than with the stage III (P<0.05). Mortality accounted for 14.93%， infection rate 77.61% and bleeding rate 26.87% in the patients with ARF. Peripheral WBC count， PLT， MPV， PDW， and PCT were better in patients without complications than with complications (P<0.05). Conclusion： Detection of peripheral WBC count and PLT parameters play an important role in evaluation of the severity and prognosis of ARF., http://www.100md.com(刘喜龙 谢琳瑛 何志红)