贯叶连翘治疗抑郁症的药理机制及临床应用和市场调研

    安泳潼 刘力 赵亚红*

    (上海医药集团有限公司中央研究院 上海 201203)

    摘 要抑郁症为常见精神疾病，近年来其诊断和治疗取得长足进步。天然抗抑郁药物的研究与开发成为新热点，贯叶连翘制剂为其中代表药物。本文对贯叶连翘治疗抑郁症的药效机制、上市品种的临床疗效和不良反应、市场销售以及在研品种的进展情况作一综述。

    关键词抑郁症 贯叶连翘 药效机制 临床研究 市场销售

    Pharmacological mechanism of St. John’s wort for the treatment of depression and its clinical application and sales

    AN Yongtong, LIU Li, ZHAO Yahong*

    (Central Research Institute, Shanghai Pharmaceutical Holding Co. Ltd., Shanghai 201203, China)

    ABSTRACTDepression is a kind of common mental disease and great progress has been made in its diagnosis and treatment in recent years. The research and development of natural antidepressant drugs become the new hot spots and St John’s wort is one of the representatives. This review introduces the pharmacological mechanism of St John’s wort, the clinical application and market sales of listed varieties and the progress of varieties in development.

    KEY WORDSdepression; St John’s wort; pharmacological mechanism; clinical application; market sales

    抑郁症已成为现代社会的常见病，发病率逐年攀升。既往临床治疗中超过30% 的患者对多种抗抑郁药物治疗无效 ......