腺病毒冻干条件的改进研究(1)
摘 要 目的：提高腺病毒制品的稳定性。方法：采用冷冻干燥技术制备腺病毒冻干制剂。结果：腺病毒冻干制品在 4 ℃放置12个月，活性(病毒滴度)下降不超过10%。结论：改进后的腺病毒冻干制剂在临床上作为基因治疗的载体有较好的应用前景。
关键词 腺病毒 冷冻干燥 稳定性
中图分类号：R944 文献标识码：A 文章编号：1006-1533(2017)13-0067-03
Preliminary research for the preparation of adenovirus lyophilized reagent
FU Hui*， GU Jing
(Shanghai Sunway Biotech Co.， Ltd.， Shanghai 201206， China)
ABSTRACT Objective： To improve the stability of adenovirus in lyophilized reagent. Methods： Adenovirus reagent was lyophilized by freeze-drying method. Results： The activity of adenovirus was decreased less than 10% in lyophilized reagent after it was stored at 4 ℃ for 12 months. Conclusion： The improved adenovirus lyophilized reagent possesses better application prospects in clinic as a vector for gene therapy.
KEY WORDS adenovirus； freeze-drying； stability
随着基因治疗研究的逐渐深入 ......
您现在查看是摘要页，全文长 3755 字符。
关键词 腺病毒 冷冻干燥 稳定性
中图分类号：R944 文献标识码：A 文章编号：1006-1533(2017)13-0067-03
Preliminary research for the preparation of adenovirus lyophilized reagent
FU Hui*， GU Jing
(Shanghai Sunway Biotech Co.， Ltd.， Shanghai 201206， China)
ABSTRACT Objective： To improve the stability of adenovirus in lyophilized reagent. Methods： Adenovirus reagent was lyophilized by freeze-drying method. Results： The activity of adenovirus was decreased less than 10% in lyophilized reagent after it was stored at 4 ℃ for 12 months. Conclusion： The improved adenovirus lyophilized reagent possesses better application prospects in clinic as a vector for gene therapy.
KEY WORDS adenovirus； freeze-drying； stability
随着基因治疗研究的逐渐深入 ......
您现在查看是摘要页，全文长 3755 字符。