王艳艳 刘长河 葛文静 李华妮

    摘 要 目的：比较感冒清热颗粒挥发油包合物的3种不同制备方法，筛选最佳的制备工艺。 方法：以挥发油包合率、包合物收得率综合评分为指标，采用正交试验方法对饱和溶液法、研磨法和超声法包合挥发油的工艺进行比较。 结果：饱和溶液法包合率和收得率分别为90.0%和78.8%；研磨法包合率和收得率分别为91.1%和73.3%；超声法包合率和收得率分别为74.3%和72.9%。 结论：研磨法制备挥发油包合物具有时间短、包合率和收得率较高的特点，优于饱和溶液法和超声法，并且包合物具有一定的抗光照性、热及湿稳定性。

    关键词 感冒清热颗粒 挥发油 β-环糊精 包合工艺

    中图分类号：R283 文献标志码：A 文章编号：1006-1533(2020)17-0065-06

    *基金项目：河南省科技攻关项目(2017zyo6o9)

    Comparative study on the process of including volatile oil from Ganmaoqingre granules with β-cyclodextrin and its stability*

    WANG Yanyan**， LIU Changhe***， GE Wenjing， LI Huani

    (Henan Provincial Academy of Traditional Chinese Medicine and Pharmacy， Zhengzhou 450004， China)

    ABSTRACT Objective： Three different methods for the preparation of volatile oil inclusion compound of Ganmaoqingre granules were compared and the best one was screened out. Methods： The processes for the volatile oil inclusion prepared by saturated solution method ......