丁天凌

    摘 要 目的：探讨布鲁顿酪氨酸激酶抑制剂伊布替尼治疗老年慢性淋巴细胞白血病(chronic lymphocytic leukemia， CLL)患者所致新发心房颤动的处理方法。方法：1例老年CLL患者接受伊布替尼治疗后出现新发心房颤动。查阅相关临床指南和文献，未停药，给予低剂量抗凝药利伐沙班抗凝治疗。结果：患者的CLL控制良好，且没有出现新发血栓栓塞和出血事件。结论：伊布替尼治疗老年CLL可致患者出现心房颤动。伊布替尼本身也有抗血小板作用。因此，对使用伊布替尼治疗的老年CLL患者应进行血栓栓塞和出血风险评估，以决定是否和如何进行抗凝治疗。

    关键词 布鲁顿酪氨酸激酶抑制剂 伊布替尼 慢性淋巴细胞白血病 心房颤动 抗凝治疗

    中图分类号：R979.19； R969.3 文献标志码：B 文章编号：1006-1533(2021)15-0005-03

    The management of patient with new-onset atrial fibrillation caused by ibrutinib therapy of elderly chronic lymphocytic leukemia

    DING Tianling

    (Department of Hematology， Huashan Hospital， Fudan University， Shanghai 200040， China)

    ABSTRACT Objective： To explore the management of patient with new-onset atrial fibrillation caused by ibrutinib therapy of elderly chronic lymphocytic leukemia (CLL). Methods： New-onset atrial fibrillation occurred in an elderly CLL patient after receiving ibrutinib therapy. The drug was not discontinued and the low-dose anticoagulant rivaroxaban was given for anticoagulant treatment by consulting the relevant clinical guidelines and literature. Results： The CLL of the patient was well controlled ......