吴姗姗

    摘 要 结核病由结核分枝杆菌感染引起，是一类慢性、传染性和致命性的疾病。随着耐多药和广泛耐药结核分枝杆菌的不断出现与快速传播，结核病治疗变得更加艰难，寻找新药成为当务之急。本文介绍近年来抗结核新药的研发进展。

    关键词 抗结核药物 结核病 结核分枝杆菌

    中图分类号：R978.3 文献标志码：A 文章编号：1006-1533(2021)21-0011-05

    Research progress of new antituberculosis drugs

    WU Shanshan

    (Department of Pharmacy， Shanghai Public Health Clinical Center， Shanghai 201508， China)

    ABSTRACT Tuberculosis is caused by the Mycobacterium tuberculosis and is a chronic， infectious and fatal disease. Its treatment becomes more difficult due to the emergence and rapid spread of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. So it is urgent to find new drugs. The new drugs found in recent years are briefly described so as to provide a reference for the research and development of new antituberculosis drugs.

    KEy wORDS antituberculosis drugs； tuberculosis； Mycobacterium tuberculosis

    肺結核是一种传染性疾病，通常情况下仅影响肺部，但约25%患者的结核分枝杆菌(以下简称“结核杆菌”)会通过血液进入并感染身体的其他部位，如胸膜、脑膜、淋巴系统、泌尿生殖系统、骨骼和关节等 ......