吴薇 李晓宇 吕迁洲

    摘 要 目的：探讨临床药师在救治药源性急性肾功能衰竭中的药学服务作用。方法：以1例大剂量甲氨蝶呤致淋巴瘤患者急性肾功能衰竭的药物治疗过程为例，根据患者的病情变化和治疗效果及时调整治疗方案，并对患者进行药学监护。结果：临床药师通过参与患者的药学监护，提出药学建议，促进临床用药的安全性，改善临床治疗结局。结论：临床药师参与药源性急性肾功能衰竭的救治，可以为患者提供个体化给药方案，并且提高了临床对药源性疾病的认识，优化药物治疗方案，为今后的用药提供参考依据。

    关键词 大剂量甲氨蝶呤 急性肾功能衰竭 药学监护

    中图分类号： R979.12； R692.5 文献标志码：B 文章编号：1006-1533(2021)23-0086-05

    Clinical pharmacists participate in the diagnosis and treatment of a lymphoma atient with acute renal failure caused by high dose methotrexate

    WU Wei， LI Xiaoyu， LYU Qianzhou

    (Department of Pharmacy， Zhongshan Hospital， Fudan University， Shanghai 200032， China)

    ABSTRACT Objective： To explore the pharmaceutical care role of clinical pharmacists in the treatment of druginduced acute renal failure. Methods： Taking a case of acute renal failure caused by high dose methotrexate as an example， the treatment plan was adjusted in time according to the patient’s conditions and treatment effect， and meanwhile the patient was given pharmaceutical care. Results： By participating in the pharmaceutical care of the patient， clinical pharmacists put forward pharmaceutical suggestions to promote the safety of clinical medication and improve the outcomes of clinical treatment. Conclusion： Clinical pharmacists participating in the treatment of drug-induced acute renal failure can provide individualized drug delivery programs for patients and improve the clinical understanding of drug-induced diseases ......