朱飞龙 孔姗 鞠少卿

    摘 要 环状RNA是一类通过反向剪接方式形成的具有稳定闭合环状的内源性非编码RNA分子，其具有稳定的结构和高度的保守性，这些是其在不同生物中发挥重要作用的基础。胃癌是起源于胃黏膜上皮的常见恶性肿瘤，具有发病率高、发病机制复杂等特点。目前研究已证实环状RNA可以作为miRNA海绵体、与蛋白质相互作用以及调节基因表达等功能，从而参与多种疾病的发生发展。本文就环状RNA的分子特征、作用机制及其与胃癌的关系，以及环状RNA作为胃癌早期诊断、预后评估、靶向治疗的生物标志物的潜力进行综述。

    关键词 环状RNA 胃癌 生物标志物

    中图分类号：R735.2； R730 文献标志码：A 文章编号：1006-1533(2022)03-0054-05

    Classification， characteristics and functions of circular RNA and its role in the diagnosis and treatment of gastric cancer

    ZHU Feilong1， KONG Shan1， JU Shaoqing1，2(1. School of Medicine， Nantong University， Nantong 226019， China； 2. Department of Laboratory Medicine， the Hospital affiliated to Nantong University， Nantong 226001， China)

    ABSTRACT Circular RNA is a kind of endogenous non-coding RNA molecule with stable closed ring formed by reverse splicing， which has a stable structure and a high degree of conservatism and is the basis of its important role in different organisms. Gastric cancer is a common malignant tumor originating from gastric mucosal epithelium， which has the characteristics of high incidence and complex pathogenesis. At present ......