冯小双 王泽洲 郑莹

    摘 要 我国新发恶性肿瘤病例超过456万，占全球癌症总发病例数的23%，疾病负担严重。吸烟和饮酒是恶性肿瘤明確的重要危险因素，本文通过全面描述吸烟和饮酒对恶性肿瘤发病风险交互作用的近期文献报道，概述吸烟和饮酒对各类恶性肿瘤发病风险的增加存在协同作用，重点总结了针对头颈部恶性肿瘤和食管鳞癌的研究结果，提示戒烟和戒酒有助于降低两类癌症的风险，该领域的研究进展为烟草和酒精这两类常见恶性肿瘤危险因素的预防和控制提供进一步的科学证据。

    关键词 肿瘤；吸烟；饮酒

    中图分类号：R73 文献标志码：A 文章编号：1006-1533(2022)06-0007-04

    引用本文 冯小双， 王泽洲， 郑莹. 吸烟和饮酒的协同作用与恶性肿瘤发生风险的研究进展[J]. 上海医药， 2022， 43(6)： 7-10， 44.

    Review of the synergistic effects of smoking and drinking consumption on the risk of malignant tumors

    FENG Xiaoshuang， WANG Zezhou， ZHENG Ying(Department of Cancer Prevention of Cancer Hospital of Fudan University； Department of Oncology， Shanghai Medical College， Fudan University， Shanghai 200032， China)

    ABSTRACT There are more than 4.56 million new cases of malignant tumors in our country， accounting for 23% of the total number of cases of malignant tumors in the world， and the burden of disease is serious. Smoking and drinking have been identified as the most important risk factors of malignant tumors. This article comprehensively describes recent literature reports on the interaction between smoking and drinking on the risk of malignant tumors ......