摘 要 1例73岁老年女性重症骨质疏松者行髋关节置换术后，采用地舒单抗抗骨质疏松，6 d后主诉下肢有抽搐感，复查血钙2.0 mmol/L。临床药师结合患者症状和用药史，判断与地舒单抗注射液不良反应有关，及时调整医嘱，加用葡萄糖酸钙颗粒和骨化三醇胶丸促进钙的吸收，纠正低钙血症。临床药师积极参与治疗方案的制定，提供全程化的药学服务，保证重症高危骨质疏松患者的治疗效果，保障患者用药安全，提高患者的预后和生活质量。

    关键词 骨质疏松 地舒单抗 药学监护 临床药师

    中图分类号：R977.9； R589.9 文献标志码：B 文章编号：1006-1533(2024)05-0070-03

    引用本文 林燕， 刘晓琰. 临床药师参与1例地舒单抗治疗重症骨质疏松患者的药学监护[J]. 上海医药， 2024， 45(5)： 70-72.

    Clinical pharmacist participates in the pharmacological monitoring of a patient with severe osteoporosis treated with denosumab

    LIN Yan， LIU Xiaoyan

    (Department of Pharmacy， Huangpu Branch， Shanghai Ninth People’s Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200011， China)

    ABSTRACT A 73 year old female patient with severe osteoporosis underwent hip arthroplasty and was then treated with denosumab for osteoporosis. After 6 days， the patient complained of convulsions in the lower limbs and her blood calcium content was 2.0 mmol/L after follow-up examination. The clinical pharmacists judged that this adverse reaction was associated with denosumab injection by considering her symptoms and medication history ......