摘 要 正常状态下，人体与肠道微生物群互利共生。肠道微生物群已被证实与多种疾病相关，而肝脏作为肠道的比邻器官，无论是在解剖学上还是在功能上都与肠道密切相关。罹患肝病时，肠道微生物群组成发生显著变化，且该变化还会进一步促进肝病进展。本文介绍不同肝病状态下肠道菌群及其代谢物的变化和这种变化对肝病进展的影响，以帮助同人深入认识肠道菌群变化与肝病发生发展之间的关联，进而共同探索基于肠道微生态的肝病预防和治疗新策略。

    关键词 肠道菌群 药物性肝损伤 自身免疫性肝病 代谢相关脂肪性肝病 肝硬化 肝癌

    中图分类号：R333.3； R575 文献标志码：A 文章编号：1006-1533(2024)19-0003-04

    引用本文 张会禄， 潘亦达， 陈坚. 肠道菌群及其代谢与肝脏疾病[J]. 上海医药， 2024， 45(19)： 3-6； 11.

    Relationship between gut microbiota and its metabolites and liver diseases

    ZHANG Huilu， PAN Yida， CHEN Jian

    (Department of Gastroenterology， Huashan Hospital， Fudan University， Shanghai 200040， China)

    ABSTRACT The human body and the gut microbiota are mutually beneficial and symbiotic under normal conditions. The gut microbiota has been proven to be associated with various diseases， and the liver， as a neighboring organ， is closely related to the gut both anatomically and functionally. Numerous studies have shown that the composition of gut microbiota undergoes significant changes when suffering from liver disease and the changes can significantly affect the development of liver diseases. This review summarizes the changes in gut microbiota and its metabolites under different liver disease states and their impact on the occurrence and development of liver disease to help colleagues deeply understand the relationship between the changes in gut microbiota and the development of liver disease ......