摘 要 机体内的硫化氢是一种微量气体信号分子，在肠道中由肠上皮细胞和肠道菌群代谢产生。越来越多的研究表明，结直肠癌患者伴有肠道菌群失衡和体内硫化氢水平增高现象。本文概要介绍机体内硫化氢的产生途径及其生理和病理作用，并讨论了未来呼出气中硫化氢水平用于结直肠癌筛查与预警的可能性。

    关键词 结直肠癌 硫化氢 肠道菌群 胱硫醚β-合酶

    中图分类号：R333.3； R735.3 文献标志码：A 文章编号：1006-1533(2024)19-0012-04

    引用本文 陈坚， 张会禄， 潘亦达， 等. 硫化氢与结直肠癌[J]. 上海医药， 2024， 45(19)： 12-15； 21.

    Hydrogen sulfide and colorectal cancer

    CHEN Jian， ZHANG Huilu， PAN Yida， LIU Jie

    (Department of Gastroenterology， Huashan Hospital， Fudan University， Shanghai 200040， China)

    ABSTRACT Hydrogen sulfide is a trace gas signaling molecule that is metabolized in the gut by intestinal epithelial cells or intestinal microbiota using cysteine as its substrate. More and more studies have confirmed that patients with colorectal cancer are accompanied by gut flora disturbance and an increase in the level of hydrogen sulfide synthesis in the body. The pathway of hydrogen sulfide production and its physiological and pathological effects in colorectal cancer were reviewed in the present paper. The value of exhaled hydrogen sulfide in screening and early prediction of colorectal cancer as a novel target was also discussed. ......