摘 要 目的：社区获得性肺炎(CAP)是儿童住院和死亡的主要原因，本研究旨在从CAP中筛选免疫相关的基因。方法：从GEO数据库获取CAP数据，利用生物信息学方法筛选免疫相关基因，并进一步探究这些基因的功能及其与免疫细胞的关系。结果：CAP疾病组与正常组之间的差异基因主要与抗原加工和递呈、核糖体、细胞凋亡和炎症反应等功能相关。WGCNA和PPI分析共确定了10个免疫相关的关键基因：IL4R、FGR、CCR3、CCR1、ARG1、CEBPB、IL17RA、NFKBIA、PPARG和NCF4。这些基因的表达水平与免疫细胞的浸润水平呈显著的相关性。结论：本研究筛选出了可能在CAP免疫反应中起重要作用的基因。

    关键词 社区获得性肺炎 免疫 儿童 呼吸道感染

    中图分类号：R563 文献标志码：A 文章编号：1006-1533(2024)21-0053-07

    引用本文 董海丽， 王国胜， 谷双龙， 等. 社区获得性肺炎免疫相关基因的鉴定与分析[J]. 上海医药， 2024， 45(21)： 53-59； 75.

    Identification and analysis for immune-related genes in community-acquired pneumonia

    DONG Haili， WANG Guosheng， GU Shuanglong， SONG Nanping

    (Department of Pediatrics， Zhengzhou 460 Hospital， Zhengzhou 450000， China)

    ABSTRACT Objectives： Community-acquired pneumonia (CAP) is a leading cause of hospitalization and death in children. The present study mainly aimed to screen out immune-related genes in CAP. Methods： CAP data were retrieved from GEO online database. The immune-related genes were identified using bioinformatics method， and their function and relationship with immune cells were further investigated. Results： The differential expressed genes between CAP group and normal group were mainly related to antigen processing and presentation ......