【摘要】目的：评价曲美他嗪(TMZ)治疗老年人不稳定型心绞痛(UAP)的疗效及耐受性。方法：120例老年UAP患者随机分为治疗组和对照组，治疗组给予基础治疗加用曲美他嗪40mg每日3次，共治疗12周，对照组只给予基础治疗。两组心绞痛发作情况、动态心电图、副作用及肾功能进行对比分析。结果： 12周后治疗组与对照组比较：①心绞痛发作次数、硝酸甘油消耗量明显减少 (P<0.01)，心绞痛程度明显改善(P<0.01)。②动态心电图缺血性ST段检出率、总缺血时间及最大ST段压低的变化，均有显著性改善 (P<0.05)。③未出现不良反应、肾功能无明显变化。结论：曲美他嗪可以使老年人不稳定型心绞痛患者的心绞痛症状减轻，运动耐量增加，缺血阈改善，且耐受性良好。

    【关键词】曲美他嗪；不稳定型心绞痛；老年人

    The anti-anginal effects and safety of trimetazidine in old patients with unstable angina

    XU Chuan-de REN Hong-mei

    【Abstract】Objective：To assess the anti-anginal efficacy and the safety of trimetazidine(TMZ)in combination with conventional treatment in old patients with unstable angina.Methods：120 oldpatients with unstable angina were randomly divided into TMZ group and control group.Both groups were given conventionaI treatment：nitrates ......