【摘要】目的:观察度洛西汀对卒中后抑郁焦虑及神经功能康复的影响。方法:将卒中后抑郁焦虑的46例患者随机分为治疗组和对照组各23例,在接受脑血管病常规治疗的基础上,治疗组加用度洛西汀,分别于治疗前及治疗4、8w后进行神经功能缺损程度评分(NDS),汉密尔顿抑郁和焦虑量表(HAMD、HAMA)评测,比较两组的疗效。结果:治疗组的神经功能缺损评分减少的百分率显著高于对照组(P<0.01)。治疗组的HAMD、HAMA评分减少的百分率显著高于对照组(P<0.01)。结论:度洛西汀治疗卒中后抑郁焦虑是有效的,而且对卒中后神经功能的恢复有一定的作用。

    【关键词】 抑郁;焦虑;卒中;治疗;度洛西汀

    The impact of Duloxetine on the post-stroke effective disorder and neurological function rehabititation

    MA Hong-yu1 CHEN Fang-tao2

    【Abstract】 Objective:To observe the effects and adverse reactions of Duloxetine on the post-stroke depression and anxiety and neurological function rehabilitation. Methods:46 patients with post-stroke depreddion and anriety were randomly divided into the treatment group and the control group ,with 23 cases in each group .The treatment group added Duloxetine on the basis of the routine treatment of cerebrovascular disease .These patients were assessed by NDS,HAMD,HAMA,respectively before and after treatment for 4、8,weeks, in order to compare the efficacy of the two groups.Results:The NDS decerased sigrificantly more in the treatment group than in the control group (P<0.01).The percentage of decline of HAMD score, HAMA score in the treatment group were significantly higher than in the control group (P<0.01). Conclusion Duloxetine is effective in the treatment of post-stroke depression and anxiety , moreover it has a certain role for post-stroke neurological function rehabilitation. ......