摘要：目的 为治疗骨不连的动物实验研究建立一种客观的实验模型。方法 测量兔股骨中段的直径和矢状径，用于指导模型的制备。制备股骨骨折不连模型，骨折断端用骨蜡封闭髓腔。术后12w经过大体标本观察、影像学及病理组织学检查确定骨不连情况。结果 经过大体观察、组织学及影像学检查均表明骨缺损区为纤维瘢痕组织填充，无骨性连接，断端硬化，髓腔封闭。结论 本实验所建立的兔股骨骨折不连模型，具有骨不连的影像学及病理组织学改变，符合骨不连的要求，是一种实用且可靠的骨不连动物模型。

    关键词：骨不连；股骨；缺损长度；动物模型；外固定架

    Abstract： Objective To establish an objective animal model for experimental study of treating bone nonunion. Methods The diameter and sagittal diameter of middle rabbit femur were obtained through measurement in order guide the operation. To establish rabbit models of femoral bone nonunion.The bone marrow cavity was sealed by bone-wax.The model of femoral bone nonunion was observed by gross ......