肿瘤标志物在肺癌辅助诊断中的应用(1)
摘要：目的 肺癌肿瘤标志物在肺癌诊断、复发、手术评估方面均有较高价值，本研究探讨5种血清肿瘤标志物神经原特异性烯醇化酶(NSE)、癌胚抗原(CEA)、癌抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)和鳞状细胞癌抗原(SCC)在肺癌辅助诊断中的应用价值，及敏感性和特异性最高的肿瘤标志物组合。方法 收集120例肺癌患者，80例健康人和98例肺部良性疾病患者血清。以上5种标志物水平均采用酶联免疫吸附实验(ELISA)检测。结果 肺癌患者的5种血清肿瘤标志物水平均明显高于非肿瘤组、健康组和良性疾病组，差异有统计学意义(P<0.01)。其中NSE在小细胞肺癌、CYFRA21-1、鳞癌抗原(SCC)在鳞癌中的水平明显高于其他类型的肺癌；NSE对小细胞肺癌检测的敏感性明显高于其他类型的肺癌； 以上5种血清癌标志物经组合后，敏感性明显高于任一单项癌标志物(P<0.01)。结论 5种血清肿瘤标志物对于肺癌的辅助诊断有一定的临床意义。
关键词：肺肿瘤标志物；诊断学；肺癌
, http://www.100md.com
Abstract：Objective Lung cancer tumor markers in lung cancer diagnosis and assessment of recurrence， surgery has a higher value，.This study of 5 kinds of serum tumor markers in diagnosis of lung cancer application， including the neuron-specific enolase (NSE) and carcinoembryonic Antigen (CEA) and cancer Antigen 125 (CA125) and Cytokeratin 19 fragment () and squamous cell carcinoma Antigen (SCC)；Methods 120 cases of patients with lung cancer， 80 healthy and Sera of 98 patients with benign disease.Above 5 kinds of markers are made of Elisa experiments (ELISA) testing.Results 5 kinds of serum tumor markers in patients with lung cancer are significantly higher than the non-tumor group and healthy groups and benign disease group， a statistically significant difference (P<0.01). NSE in small cell lung cancer， CYFRA21-1 and squamous cell carcinoma Antigen (SCC) Squamous cell carcinomas were significantly higher than those in other types of lung cancer (P<0.01)； Detection sensitivity of NSE for small cell lung cancer was significantly higher than other types of lung cancer (P<0.01)； More than 5 kinds of serum tumor markers combination， sensitivity was significantly higher than any single cancer markers (P<0.01).Conclusion 5 kinds of serum tumor markers for lung cancer diagnosis has clinical significance. NSE can be used as a marker for detection of small cell lung cancer；CEA +CYFRA21-1+SCC can be used to inspect non-small cell lung cancer with combination of markers. CYFRA21-1+SCC can be used to inspect combinations of markers in lung squamous cell carcinoma.
, http://www.100md.com
Key words：Lung tumor markers； Diagnosis；Lung cancer
随着肿瘤发病率上升及患病年轻化，肿瘤的早期诊断和治疗受到了前所未有的重视。肿瘤标志物的研究与应用对肿瘤的早期诊断治疗开创了新领域。肿瘤患者血清中肿瘤标志物的量发生改变时，能够揭示某种肿瘤的存在[1]。肿瘤标志物在肿瘤普查、诊断、判断预后和转归，评价疗效等方面具有较大实用价值。在临床上肿瘤标志物已成为肿瘤患者的重要检查指标[2]。因此，我们对目前应用于临床检测肺癌的5种血清肿瘤标志物(CEA、NSE、CYFRA21-1、SCC、CA125)进行了研究，目的是评价其在肿瘤诊断中的价值，并选择最理想的标志物组合以提高检测肺癌的敏感性。
1资料与方法
1.1一般资料
1.1.1健康成人组收集我院体检科健康成人80例，其中男51例，女29例；平均年龄41岁。
1.1.2良性疾病组均为我院呼吸科、感染内科2014年1月～7月住院患者。肺结核患者58例，其中男35例，女23例；平均年龄36岁，一般肺感染患者40例，其中男23例，女17例；平均年龄65岁。, http://www.100md.com(韩宾)
关键词：肺肿瘤标志物；诊断学；肺癌
, http://www.100md.com
Abstract：Objective Lung cancer tumor markers in lung cancer diagnosis and assessment of recurrence， surgery has a higher value，.This study of 5 kinds of serum tumor markers in diagnosis of lung cancer application， including the neuron-specific enolase (NSE) and carcinoembryonic Antigen (CEA) and cancer Antigen 125 (CA125) and Cytokeratin 19 fragment () and squamous cell carcinoma Antigen (SCC)；Methods 120 cases of patients with lung cancer， 80 healthy and Sera of 98 patients with benign disease.Above 5 kinds of markers are made of Elisa experiments (ELISA) testing.Results 5 kinds of serum tumor markers in patients with lung cancer are significantly higher than the non-tumor group and healthy groups and benign disease group， a statistically significant difference (P<0.01). NSE in small cell lung cancer， CYFRA21-1 and squamous cell carcinoma Antigen (SCC) Squamous cell carcinomas were significantly higher than those in other types of lung cancer (P<0.01)； Detection sensitivity of NSE for small cell lung cancer was significantly higher than other types of lung cancer (P<0.01)； More than 5 kinds of serum tumor markers combination， sensitivity was significantly higher than any single cancer markers (P<0.01).Conclusion 5 kinds of serum tumor markers for lung cancer diagnosis has clinical significance. NSE can be used as a marker for detection of small cell lung cancer；CEA +CYFRA21-1+SCC can be used to inspect non-small cell lung cancer with combination of markers. CYFRA21-1+SCC can be used to inspect combinations of markers in lung squamous cell carcinoma.
, http://www.100md.com
Key words：Lung tumor markers； Diagnosis；Lung cancer
随着肿瘤发病率上升及患病年轻化，肿瘤的早期诊断和治疗受到了前所未有的重视。肿瘤标志物的研究与应用对肿瘤的早期诊断治疗开创了新领域。肿瘤患者血清中肿瘤标志物的量发生改变时，能够揭示某种肿瘤的存在[1]。肿瘤标志物在肿瘤普查、诊断、判断预后和转归，评价疗效等方面具有较大实用价值。在临床上肿瘤标志物已成为肿瘤患者的重要检查指标[2]。因此，我们对目前应用于临床检测肺癌的5种血清肿瘤标志物(CEA、NSE、CYFRA21-1、SCC、CA125)进行了研究，目的是评价其在肿瘤诊断中的价值，并选择最理想的标志物组合以提高检测肺癌的敏感性。
1资料与方法
1.1一般资料
1.1.1健康成人组收集我院体检科健康成人80例，其中男51例，女29例；平均年龄41岁。
1.1.2良性疾病组均为我院呼吸科、感染内科2014年1月～7月住院患者。肺结核患者58例，其中男35例，女23例；平均年龄36岁，一般肺感染患者40例，其中男23例，女17例；平均年龄65岁。, http://www.100md.com(韩宾)