不同剂量叶酸联合降压治疗对高血压患者靶器官的保护作用(1)
摘要：目的 观察不同剂量叶酸联合降压治疗对高血压患者多个靶器官的保护作用。方法 选择本院收治的300例高血压患者，随机分成A、B、C三组。A组为对照组，采用常规降压治疗；B组、C组为实验组采用不同剂量叶酸联合降压治疗。观察三组患者Hcy、肾功能、心脏事件、脑卒中等情况。结果 实验组Hcy水平明显下降，肾功能明显改善，心脑血管时间发生率降低，和对照组相比较有统计学意义(P<0.001)，但两实验组间对比没有显著意义(P>0.05)。结论 叶酸联合降压治疗能降低高血压患者心脑血管事件发生率，对多个靶器官有保护作用，但相对服用5 mg叶酸联合降压治疗高血压，单纯加大剂量叶酸服用量对保护高血压患者多个靶器官没有显著意义。
关键词：叶酸；剂量；高血压；靶器官；心脑血管；肾功能
The Protective Effect of Different Doses of Folic Acid Combined with Antihypertensive Treatment on the Target Organs of Patients with Hypertension
, 百拇医药
YU Yong
(Nanhai District Luo Village Hospital，Foshan 528226，Guangdong，China)
Abstract：Objective To observe the protective effects of different doses of folic acid combined with anti-hypertensive treatment treatment on multiple target organs in patients with hypertension. Methods Select my hospital 300 cases of hypertension patients were randomly divided into B， A， C three groups.A group as the control group， the use of conventional anti-hypertensive treatment；B group and C group were treated with different doses of folic acid in the experimental group.Observe the three groups of patients with Hcy， renal function， cardiac events， stroke， etc.. Results The level of Hcy in experimental group decreased significantly， renal function improved significantly， reduce the incidence of cardiovascular and cerebrovascular time， compared with the control group had statistical significance (P<0.001).But there was no significant difference between the two experimental groups (P>0.05). Conclusion The treatment of folic acid combined with blood pressure can reduce the incidence of cardiovascular events in patients with hypertension， has a protective effect on multiple target organs， But the relative use of 5mg folic acid combined with anti-hypertensive treatment of high blood pressure， only to increase the dose of folic acid to protect hypertensive patients with multiple target organs is not significant.
, http://www.100md.com
Key words：Folic acid；Dosage；High blood pressure；Target organ；Cardiovascular and cerebrovascular；Renal function
高血压是我国主要多发性慢性病之一，同时也是心脑血管病最主要的危险因素，其主要并发症有：脑卒中、心肌梗死、心力衰竭及慢性肾脏病等，不仅致残率高，而且致死率也极高。根据《中国高血压指南》2010年版的治疗原则，约有3/4的高血压患者血液中伴有高含量的同型半胱氨酸(Hcy)。流行病学的研究发现，Hcy是动脉硬化、脑卒中的独立危险因素[1]。近年来国内外大量研究表明，补充叶酸能明显降解血浆Hcy水平，减缓动脉粥样硬化，保护心脑肾等重要靶器官及预防心血管事件有重要意义，但叶酸使用剂量相差很大。本研究拟观察不同剂量叶酸联合降压治疗对高血压患者多个靶器官的保护作用，为叶酸联合降压治疗的推广应用提供依据。
1 资料与方法
1.1一般资料 选择2012年5月～2013年6月佛山市南海区罗村医院收治的高血压患者共300例，其中男性188例，女性112例，年龄平均59.1岁，病程4～12年。作为本次研究观察对象，按照数字表法随机分成A、B、C三组各100例。三组患者在性别、年龄、病程等因素分布情况无统计学意义(P>0.05)。, 百拇医药(余泳)
关键词：叶酸；剂量；高血压；靶器官；心脑血管；肾功能
The Protective Effect of Different Doses of Folic Acid Combined with Antihypertensive Treatment on the Target Organs of Patients with Hypertension
, 百拇医药
YU Yong
(Nanhai District Luo Village Hospital，Foshan 528226，Guangdong，China)
Abstract：Objective To observe the protective effects of different doses of folic acid combined with anti-hypertensive treatment treatment on multiple target organs in patients with hypertension. Methods Select my hospital 300 cases of hypertension patients were randomly divided into B， A， C three groups.A group as the control group， the use of conventional anti-hypertensive treatment；B group and C group were treated with different doses of folic acid in the experimental group.Observe the three groups of patients with Hcy， renal function， cardiac events， stroke， etc.. Results The level of Hcy in experimental group decreased significantly， renal function improved significantly， reduce the incidence of cardiovascular and cerebrovascular time， compared with the control group had statistical significance (P<0.001).But there was no significant difference between the two experimental groups (P>0.05). Conclusion The treatment of folic acid combined with blood pressure can reduce the incidence of cardiovascular events in patients with hypertension， has a protective effect on multiple target organs， But the relative use of 5mg folic acid combined with anti-hypertensive treatment of high blood pressure， only to increase the dose of folic acid to protect hypertensive patients with multiple target organs is not significant.
, http://www.100md.com
Key words：Folic acid；Dosage；High blood pressure；Target organ；Cardiovascular and cerebrovascular；Renal function
高血压是我国主要多发性慢性病之一，同时也是心脑血管病最主要的危险因素，其主要并发症有：脑卒中、心肌梗死、心力衰竭及慢性肾脏病等，不仅致残率高，而且致死率也极高。根据《中国高血压指南》2010年版的治疗原则，约有3/4的高血压患者血液中伴有高含量的同型半胱氨酸(Hcy)。流行病学的研究发现，Hcy是动脉硬化、脑卒中的独立危险因素[1]。近年来国内外大量研究表明，补充叶酸能明显降解血浆Hcy水平，减缓动脉粥样硬化，保护心脑肾等重要靶器官及预防心血管事件有重要意义，但叶酸使用剂量相差很大。本研究拟观察不同剂量叶酸联合降压治疗对高血压患者多个靶器官的保护作用，为叶酸联合降压治疗的推广应用提供依据。
1 资料与方法
1.1一般资料 选择2012年5月～2013年6月佛山市南海区罗村医院收治的高血压患者共300例，其中男性188例，女性112例，年龄平均59.1岁，病程4～12年。作为本次研究观察对象，按照数字表法随机分成A、B、C三组各100例。三组患者在性别、年龄、病程等因素分布情况无统计学意义(P>0.05)。, 百拇医药(余泳)