泮托拉唑和奥美拉唑治疗2型糖尿病并发消化性溃疡出血的对比(1)
摘要：目的 探讨泮托拉唑和奥美拉唑治疗2型糖尿病并发消化性溃疡出血的疗效。方法 收集2012年1月～2015年8月我院诊断为2型糖尿病并发消化性溃疡出血的患者，基础疾病为2型糖尿病。随机分为两组，研究组50例(接受泮托拉唑治疗)和对照组50例(接受奥美拉唑治疗)，余治疗方法两组相同。结果 ①研究组和对照组消化性溃疡出血的治愈率分别为96%、82%，结果比较有差异(P<0.05)。②研究组和对照组消化性溃疡出血停止时间分别为(28.2±7.2)h、(35.8±9.2)h，结果比较有差异(P<0.05)。③研究组和对照组用药期间不良反应(恶心、头晕、口干、便秘、皮疹)发生率分别为6%、10%，结果比较无差异(P>0.05)。结论 本次研究认为相对于奥美拉唑，泮托拉唑治疗2型糖尿病并发消化性溃疡出血疗效肯定，能在短期内改善患者症状。
关键词：泮托拉唑；奥美拉唑；2型糖尿病；消化性溃疡；出血
Comparison of Type 2 Diabetes Mellitus Complicated with Peptic Ulcer Hemorrhage Treated with Pantoprazole and Omeprazole
, http://www.100md.com
PANG Xue-hua
(The First People's Hospital of Shuangliu District，Chengdu 610200，Sichuan，China)
Abstract：Objective To investigate the curative effect of pantoprazole and omeprazole in the treatment of diabetes mellitus complicated with peptic ulcer bleeding type 2.Methods Collected in August January 2012-2015 in our hospital diagnosed type 2 diabetes mellitus complicated with peptic ulcer bleeding in patients with basic disease for type 2 diabetes.Were randomly divided into 2 groups，the study group 50 cases(received pantoprazole treatment)and the control group(50 cases)received omeprazole，Yu treatment two groups of the same.Results ①The cure rate of peptic ulcer bleeding in the study group and the control group were 96%and 82%，respectively，and the results were quite different(P<0.05).②In the study group and control group，the bleeding time of peptic ulcer bleeding was 28.2±7.2 hours，35.8±9.2 hours，and the results were quite different(P<0.05).③In the study group and control group，medication period adverse effects(nausea，dizziness，dry mouth，constipation，skin rash，occurrence rate of 6%and 10%respectively.As a result，there is no significant difference(P>0.05).Conclusion This study that compared with omeprazole，pantoprazole in treatment of type 2 diabetes mellitus complicated with digestive ulcer hemorrhage curative effect，can improve the symptoms in the short term.
, 百拇医药
Key words：Pantoprazole；Omeprazole；Type 2 diabetes；Peptic ulcer；Hemorrhage
泮托拉唑和奥美拉唑同为质子泵抑制剂，在临床上广泛用于消化道溃疡的治疗。因此本次研究拟收集2012年1月～2015年8月我院诊断为2型糖尿病并发消化性溃疡出血的患者，探讨泮托拉唑和奥美拉唑的治疗差异。
1 资料与方法
1.1一般资料 收集2012年1月～2015年8月我院诊断为2型糖尿病并发消化性溃疡出血的患者，基础疾病为2型糖尿病。随机分为两组，研究组50例(接受泮托拉唑治疗)和对照组50例(接受奥美拉唑治疗)，余治疗方法两组相同。研究组平均年龄(58.3±16.8)岁，其中男性28例，女性22例；对照组平均年龄(52.9±17.9)岁，其中男性27例，女性23例。两组人员性别，年龄，疾病类型上差异无统计学意义。
1.2入选标准 ①2型糖尿病诊断符合第8版《实用内科学》制定的标准；②消化性溃疡符合第8版《实用内科学》制定的标准，有呕血或呕吐咖啡样物与黑便，呕吐物隐血或大便隐血阳性，胃镜检查支持。③肝肾功能正常。
1.3排除指标 对本次研究药品过敏者。, http://www.100md.com(庞雪花)
关键词：泮托拉唑；奥美拉唑；2型糖尿病；消化性溃疡；出血
Comparison of Type 2 Diabetes Mellitus Complicated with Peptic Ulcer Hemorrhage Treated with Pantoprazole and Omeprazole
, http://www.100md.com
PANG Xue-hua
(The First People's Hospital of Shuangliu District，Chengdu 610200，Sichuan，China)
Abstract：Objective To investigate the curative effect of pantoprazole and omeprazole in the treatment of diabetes mellitus complicated with peptic ulcer bleeding type 2.Methods Collected in August January 2012-2015 in our hospital diagnosed type 2 diabetes mellitus complicated with peptic ulcer bleeding in patients with basic disease for type 2 diabetes.Were randomly divided into 2 groups，the study group 50 cases(received pantoprazole treatment)and the control group(50 cases)received omeprazole，Yu treatment two groups of the same.Results ①The cure rate of peptic ulcer bleeding in the study group and the control group were 96%and 82%，respectively，and the results were quite different(P<0.05).②In the study group and control group，the bleeding time of peptic ulcer bleeding was 28.2±7.2 hours，35.8±9.2 hours，and the results were quite different(P<0.05).③In the study group and control group，medication period adverse effects(nausea，dizziness，dry mouth，constipation，skin rash，occurrence rate of 6%and 10%respectively.As a result，there is no significant difference(P>0.05).Conclusion This study that compared with omeprazole，pantoprazole in treatment of type 2 diabetes mellitus complicated with digestive ulcer hemorrhage curative effect，can improve the symptoms in the short term.
, 百拇医药
Key words：Pantoprazole；Omeprazole；Type 2 diabetes；Peptic ulcer；Hemorrhage
泮托拉唑和奥美拉唑同为质子泵抑制剂，在临床上广泛用于消化道溃疡的治疗。因此本次研究拟收集2012年1月～2015年8月我院诊断为2型糖尿病并发消化性溃疡出血的患者，探讨泮托拉唑和奥美拉唑的治疗差异。
1 资料与方法
1.1一般资料 收集2012年1月～2015年8月我院诊断为2型糖尿病并发消化性溃疡出血的患者，基础疾病为2型糖尿病。随机分为两组，研究组50例(接受泮托拉唑治疗)和对照组50例(接受奥美拉唑治疗)，余治疗方法两组相同。研究组平均年龄(58.3±16.8)岁，其中男性28例，女性22例；对照组平均年龄(52.9±17.9)岁，其中男性27例，女性23例。两组人员性别，年龄，疾病类型上差异无统计学意义。
1.2入选标准 ①2型糖尿病诊断符合第8版《实用内科学》制定的标准；②消化性溃疡符合第8版《实用内科学》制定的标准，有呕血或呕吐咖啡样物与黑便，呕吐物隐血或大便隐血阳性，胃镜检查支持。③肝肾功能正常。
1.3排除指标 对本次研究药品过敏者。, http://www.100md.com(庞雪花)