老年2型糖尿病患者认知障碍的相关因素分析(1)
摘要：目的 在2型糖尿病的老年患者，研究影响其认知功能下降的因素，为进一步形成快速的、有效的、科学的预防模式提供依据。 方法 选择2014年6月～2016年6月在我科住院的T2DM患者246例，使用蒙特利尔认知评估(MoCA)评分，根据评估得分，分为老年2型糖尿病认知功能正常(NC)组(n=78)和老年2型糖尿病认知障碍(CI)组(n=168)，记录两组患者一般资料、体格检查、伴发疾病和检查结果，并比较其差异。 结果 比较两组患者，年龄、BMI、教育水平、经常体育锻炼、经常与人交流、颈部动脉硬化、空腹血糖(FBG)、同型半胱氨酸(Hcy)有显著差异(P<0.05)。多因素logistic回归分析显示年龄、体质指数(BMI)、受教育程度、颈动脉硬化、Hcy升高是认知障碍的危险因素(P<0.05)，且随年龄、体重增加发生认知障碍的风险增高。结论 老年2型糖尿病患者年齡、受教育程度、BMI、颈动脉硬化、Hcy升高可能是认知障碍的危险因素。
关键词：2型糖尿病；认知障碍；相关因素
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Analysis of Related Factors of Cognitive Impairment in Elderly Patients with Type 2 Diabetes Mellitus
ZOU Dong-mei，LI Dong-ping，SHAN Yong-yi TIAN Li
(Department of Endocrinology，the First People's Hospital of Xining City，Xining 810000，Qinghai，China)
Abstract：Objective To study the factors that affect the decline of cognitive function in elderly patients with type 2 diabetes mellitus， and to provide a basis for further rapid，effective and scientific prevention.Methods A total of 246 patients with T2DM were enrolled in our department from June 2014 to June 2016，using the Montreal cognitive assessment(MoCA)score，according to the assessment score，divided into elderly type 2 diabetes mellitus with normal cognitive function(NC)group(n=78)and cognitive impairment in elderly patients with type 2 diabetes mellitus(CI)group(n=168)，physical examination record data，two groups of patients，concomitant diseases and examination results，and compare the the difference.Results The level of education were compared between the two groups，age，BMI，educational level，regular physical exercise，often communicate with people，carotid atherosclerosis，fasting blood glucose(FBG)，homocysteine(Hcy) had significant difference (P<0.05).Multivariate logistic regression analysis showed that age，body mass index(BMI)，education the degree of carotid atherosclerosis，Hcy levels were risk factors of cognitive impairment (P<0.05)，and with age， the risk of weight gain cognitive handicap age increased.Conclusion Elderly patients with type 2 diabetes，education level，BMI，carotid atherosclerosis， elevated Hcy may be a risk factor for cognitive impairment.
, http://www.100md.com
Key words：Type 2 diabetes mellitus；Cognitive impairment；Related factors
由于我国老年人口比率逐年上升和人们不良的生活习惯，糖尿病和认知障碍的患病人数不断增加，危害人类的身心健康，糖尿病引起的认知功能下降引起广泛的关心和重视。与非糖尿病患者相比，糖尿病是认知功能障碍和衰减的一种潜在风险[1]，轻度认知障碍(MCI)进一步恶化可以转化成痴呆，37%的糖尿病患者合并MCI[2]，且每1年以10%～15%的速率发展为痴呆[3]。其阻碍患者的生活自理能力，严重影响患者生存质量。目前，糖尿病患者认知障碍的发病机制不十分明确，缺乏特效药物。因此，在老年2型糖尿患者群中，研究认知功能下降的原因显得十分重要，其有助于预防、治疗和延缓糖尿病认知障碍发生及进展的预期目的，与此同时，进一步构建糖尿病认知障碍的预防管理模式提供理论基础。, http://www.100md.com(邹冬梅 李冬萍 山永仪 田立)
关键词：2型糖尿病；认知障碍；相关因素
, http://www.100md.com
Analysis of Related Factors of Cognitive Impairment in Elderly Patients with Type 2 Diabetes Mellitus
ZOU Dong-mei，LI Dong-ping，SHAN Yong-yi TIAN Li
(Department of Endocrinology，the First People's Hospital of Xining City，Xining 810000，Qinghai，China)
Abstract：Objective To study the factors that affect the decline of cognitive function in elderly patients with type 2 diabetes mellitus， and to provide a basis for further rapid，effective and scientific prevention.Methods A total of 246 patients with T2DM were enrolled in our department from June 2014 to June 2016，using the Montreal cognitive assessment(MoCA)score，according to the assessment score，divided into elderly type 2 diabetes mellitus with normal cognitive function(NC)group(n=78)and cognitive impairment in elderly patients with type 2 diabetes mellitus(CI)group(n=168)，physical examination record data，two groups of patients，concomitant diseases and examination results，and compare the the difference.Results The level of education were compared between the two groups，age，BMI，educational level，regular physical exercise，often communicate with people，carotid atherosclerosis，fasting blood glucose(FBG)，homocysteine(Hcy) had significant difference (P<0.05).Multivariate logistic regression analysis showed that age，body mass index(BMI)，education the degree of carotid atherosclerosis，Hcy levels were risk factors of cognitive impairment (P<0.05)，and with age， the risk of weight gain cognitive handicap age increased.Conclusion Elderly patients with type 2 diabetes，education level，BMI，carotid atherosclerosis， elevated Hcy may be a risk factor for cognitive impairment.
, http://www.100md.com
Key words：Type 2 diabetes mellitus；Cognitive impairment；Related factors
由于我国老年人口比率逐年上升和人们不良的生活习惯，糖尿病和认知障碍的患病人数不断增加，危害人类的身心健康，糖尿病引起的认知功能下降引起广泛的关心和重视。与非糖尿病患者相比，糖尿病是认知功能障碍和衰减的一种潜在风险[1]，轻度认知障碍(MCI)进一步恶化可以转化成痴呆，37%的糖尿病患者合并MCI[2]，且每1年以10%～15%的速率发展为痴呆[3]。其阻碍患者的生活自理能力，严重影响患者生存质量。目前，糖尿病患者认知障碍的发病机制不十分明确，缺乏特效药物。因此，在老年2型糖尿患者群中，研究认知功能下降的原因显得十分重要，其有助于预防、治疗和延缓糖尿病认知障碍发生及进展的预期目的，与此同时，进一步构建糖尿病认知障碍的预防管理模式提供理论基础。, http://www.100md.com(邹冬梅 李冬萍 山永仪 田立)
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