脑梗死急性期血清MMP—9和TIMP—1与认知功能障碍关系的研究(1)

http://www.100md.com 2017年3月5日 《医学信息》 2017年第9期

     摘要：目的 探討脑梗死急性期血清金属基质蛋白酶9，及其抑制剂基质金属蛋白酶组织抑制因子1与脑梗死后认知功能障碍的关系。方法 收集首发急性脑梗死患者84例(脑梗死组)及健康受试者40例(健康对照组)，脑梗死组根据入组14 d时MoCA评分结果分为CI组(MoCA评分<26分)、非认知障碍(non-cognitive impairment，NCI)组(MoCA评分≥26分)。采用ELISA法测定各组血清MMP-9和TIMP-1水平。结果 与健康对照组比，CI组与NCI组血清MMP-9和TIMP-1水平均显著升高(P均<0.05)，与NCI组相比，CI组MMP-9水平显著升高(P<0.05)，而TIMP-1水平显著降低(P<0.05)。Logistic回归分析显示，高MMP-9水平和高龄是脑梗死后CI的独立危险因素，而高TIMP-1水平与吸烟是脑梗死后CI的保护性因素。相关分析显示CI组MoCA评分与MMP-9水平成负相关，与TIMP-1水平呈正相关。结论 脑梗死急性期，血清高MMP-9水平是脑梗死后CI的危险因素，而高TIMP-1水平是脑梗死后CI的保护性因素。测定脑梗死急性期血清MMP-9、TIMP-1水平，当与其他预测脑梗死后CI的因子联合进行系统筛查时，可能有助于识别脑梗死后发生认知功能障碍高风险患者。
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    关键词：认知功能障碍；脑梗死；MMP-9；TIMP-1

    Study on the Relationship between Serum MMP-9 and TIMP-1 in Patients with Acute Cerebral Infarction

    YANG Xue，DOU Zhi-jie

    (Department of Neurology，Affiliated Hospital of Chengde Medical College，Chengde 067000，Hebei，China)

    Abstract：Objective To investigate the acute cerebral infarction serum matrix metalloproteinase 9 inhibitor，relationship and tissue inhibitor of matrix metalloproteinase 1 and cognitive impairment after cerebral infarction.Methods We collected 84 cases of patients with acute cerebral infarction(ACI) patients and 40 healthy subjects(healthy control group)，cerebral infarction group according to the group of 14 d MoCA the results were divided into CI group(MoCA score<26)，non cognitive impairment(non-cognitive impairment，NCI)group(MoCAscore≥26 points).The serum MMP-9 and TIMP-1 levels were determined by ELISA method.Results Compared with healthy control group，CI group and NCI group，serum MMP-9 and TIMP-1 levels were significantly increased (P<0.05)，compared with the NCI group，the level of MMP-9 in CI group was significantly higher(P<0.05)，and TIMP-1 were significantly decreased(P<0.05).Logistic regression analysis showed that high level of MMP-9 and age were independent risk factors of CI after cerebral infarction，and high TIMP-1 With the level of smoking is a protective factor of CI after cerebral infarction.Correlation analysis showed that CI group MoCA score was negatively correlated with MMP-9 levels was positively correlated with TIMP-1 levels.Conclusion The acute stage of cerebral infarction， high serum MMP-9 level is a risk factor for CI after cerebral infarction， and the high level of TIMP-1 is a protective factor of CI in serum after cerebral infarction.MMP-9，TIMP-1 levels in patients with acute cerebral infarction，and other factors when predicting CI after cerebral infarction combined systematicscreening，may contribute to the identification of cognitive dysfunction after cerebral infarction in high-risk patients., 百拇医药(杨雪 窦志杰)

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