ASRM修正子宫内膜异位症分期法指导子宫内膜异位症术后应用GnRH—a的临床研究(1)
摘要：目的 探讨ASRM修正子宫内膜异位症分期法指导子宫内膜异位症术后应用GnRH-a的临床疗效。方法 在医院2013年4月～2014年4月诊治的子宫内膜异位症行保留生育功能手术后的患者中抽取80例作研究对象，并按照ASRM修正子宫内膜异位症分期法进行分组，治疗组(n=40)根据分期法中分为Ⅰ期、Ⅱ期者术后不予药物治疗，而Ⅲ期、Ⅳ期者给予GnRH-a治疗，观察组(n=40)不管分期如何均不予药物治疗，对比两组患者术后疼痛程度、妊娠分娩率、术后复发率、药物副作用情况。结果 ①治疗组妊娠率、分娩率均高于观察组(均P<0.05)，而复发率和VAS疼痛评分显著低于观察组(均P<0.05)；②治疗组患者均无严重不良反应。结论 ASRM修正子宫内膜异位症分期法指导子宫内膜异位症术后应用GnRH-a的临床疗效确切，可明显缓解患者疼痛，并提升其妊娠率、分娩率，降低术后疾病复发率，且安全性较高。
关键词：ASRM修正子宫内膜异位症分期法；子宫内膜异位症；GnRH-a
中图分类号：R713 文献标识码：A 文章编号：1006-1959(2017)16-0050-02
, 百拇医药
Clinical Study of Applying ASRM to Repair Endometriosis after Staging Endometriosis Guided by GnRH-a
WANG Mei
(Department of Obstetrics and Gynecology，the First People's Hospital of Nankang，Nankang 341400，Jiangxi，China)
Abstract：Objective To investigate the clinical efficacy of ASRM modified endometriosis staging in the treatment of endometriosis after GnRH-a.Methods A total of 80 patients with endometriosis who had been treated in the hospital from April 2013 to April 2014 were enrolled in the study，and were grouped according to the modified ASRM endometriosis staging method，treatment group(n=40)according to the staging method is divided into phase I and II patients without drug treatment， and stage III，IV were given GnRH-a treatment，the observation group(n=40)，regardless of staging，was not treated with drugs，the degree of postoperative pain，the rate of pregnancy delivery，the rate of postoperative recurrence and the side effects of the two groups were compared.Results ①The pregnancy rate and delivery rate in the treatment group were higher than those in the observation group(P< 0.05)，while the recurrence rate and VAS pain score were significantly lower than those in the observation group(P<0.05)；②there were no serious adverse reactions in the treatment group.Conclusion The clinical curative effect of modified ASRM endometriosis stage guidance of endometriosis postoperative application of GnRH-a is effective，can significantly relieve the pain of patients，and improve the pregnancy rate and delivery rate，reduce the recurrence rate after operation，and high safety.
, http://www.100md.com
Key words：ASRM modified endometriosis staging method；Endometriosis；GnRH-a
本研究為明确ASRM修正子宫内膜异位症分期法指导子宫内膜异位症术后应用GnRH-a的临床疗效，在ASRM修正子宫内膜异位症分期法指导下对40例子宫内膜异位症行保留生育功能手术后患者进行促性腺激素释放激素类似物(GnRH-a)治疗，对同期选取的40例同类型患者不予药物治疗，现报道两组术后疼痛程度、妊娠分娩率、术后复发率、药物副作用情况如下。
1 资料与方法
1.1一般资料
纳入本次研究的80例子宫内膜异位症行保留生育功能手术后患者均为医院自2013年4月～2014年4月收治，排除合并妊娠、严重过敏史、意识不清以及严重肝肾心等发生器质性病变者，随机分成治疗组与观察组，均40例。其中，治疗组患者年龄为27～39岁，平均年龄为(34.1±1.0)岁；参考ASRM修正子宫内膜异位症分期法予以分期：Ⅰ期者9例，Ⅱ期者12例，Ⅲ期者13例，Ⅳ期者6例；观察组患者年龄为28～39岁，平均年龄为(34.1±1.1)岁；分期：Ⅰ期者8例，Ⅱ期者11例，Ⅲ期者14例，Ⅳ期者7例；两组患者均已签订知情同意书，其年龄、分期等基线资料经统计学处理，结果显示其差异无统计学意义(P>0.05)，可对比。, http://www.100md.com(王媚)
关键词：ASRM修正子宫内膜异位症分期法；子宫内膜异位症；GnRH-a
中图分类号：R713 文献标识码：A 文章编号：1006-1959(2017)16-0050-02
, 百拇医药
Clinical Study of Applying ASRM to Repair Endometriosis after Staging Endometriosis Guided by GnRH-a
WANG Mei
(Department of Obstetrics and Gynecology，the First People's Hospital of Nankang，Nankang 341400，Jiangxi，China)
Abstract：Objective To investigate the clinical efficacy of ASRM modified endometriosis staging in the treatment of endometriosis after GnRH-a.Methods A total of 80 patients with endometriosis who had been treated in the hospital from April 2013 to April 2014 were enrolled in the study，and were grouped according to the modified ASRM endometriosis staging method，treatment group(n=40)according to the staging method is divided into phase I and II patients without drug treatment， and stage III，IV were given GnRH-a treatment，the observation group(n=40)，regardless of staging，was not treated with drugs，the degree of postoperative pain，the rate of pregnancy delivery，the rate of postoperative recurrence and the side effects of the two groups were compared.Results ①The pregnancy rate and delivery rate in the treatment group were higher than those in the observation group(P< 0.05)，while the recurrence rate and VAS pain score were significantly lower than those in the observation group(P<0.05)；②there were no serious adverse reactions in the treatment group.Conclusion The clinical curative effect of modified ASRM endometriosis stage guidance of endometriosis postoperative application of GnRH-a is effective，can significantly relieve the pain of patients，and improve the pregnancy rate and delivery rate，reduce the recurrence rate after operation，and high safety.
, http://www.100md.com
Key words：ASRM modified endometriosis staging method；Endometriosis；GnRH-a
本研究為明确ASRM修正子宫内膜异位症分期法指导子宫内膜异位症术后应用GnRH-a的临床疗效，在ASRM修正子宫内膜异位症分期法指导下对40例子宫内膜异位症行保留生育功能手术后患者进行促性腺激素释放激素类似物(GnRH-a)治疗，对同期选取的40例同类型患者不予药物治疗，现报道两组术后疼痛程度、妊娠分娩率、术后复发率、药物副作用情况如下。
1 资料与方法
1.1一般资料
纳入本次研究的80例子宫内膜异位症行保留生育功能手术后患者均为医院自2013年4月～2014年4月收治，排除合并妊娠、严重过敏史、意识不清以及严重肝肾心等发生器质性病变者，随机分成治疗组与观察组，均40例。其中，治疗组患者年龄为27～39岁，平均年龄为(34.1±1.0)岁；参考ASRM修正子宫内膜异位症分期法予以分期：Ⅰ期者9例，Ⅱ期者12例，Ⅲ期者13例，Ⅳ期者6例；观察组患者年龄为28～39岁，平均年龄为(34.1±1.1)岁；分期：Ⅰ期者8例，Ⅱ期者11例，Ⅲ期者14例，Ⅳ期者7例；两组患者均已签订知情同意书，其年龄、分期等基线资料经统计学处理，结果显示其差异无统计学意义(P>0.05)，可对比。, http://www.100md.com(王媚)
参见：首页 > 医疗版 > 疾病专题 > 妇产科 > 子宫内膜异位症