妊娠早期甲状腺激素水平与妊娠期糖尿病相关性研究(1)
摘要：目的 探討妊娠早期甲状腺激素水平特点及其与妊娠期糖尿病(Gestational diabetes mellitus，GDM)的关系。方法 回顾性分析2012年1月～2013年12月于中山大学附属第一医院门诊产检的4111例孕妇，并于妊娠早期行甲状腺激素水平(TSH、FT3、FT4)检测，孕24～28 w行OGTT检测。对纳入研究的孕妇根据OGTT结果分为GDM组(n=727)及正常对照(NGT)组(n=3384)。比较两组间妊娠早期甲状腺激素水平特点，分析妊娠早期甲状腺疾病与妊娠期糖尿病的关系。结果 GDM组孕妇妊娠早期TSH明显低于对照组[(1.37±0.96) mIU/ml vs(1.53±1.12) mIU/ml，P=0.000)，FT3[(4.75±0.91)mIU/ml vs(4.60±0.73) mIU/ml， P=0.000]明显高于对照组，FT3/FT4(0.35±0.06 vs 0.34±0.06，P=0.000)两组孕妇间存在明显差异。妊娠早期亚临床甲减者并发GDM的比例为24.37%。GDM组合并亚临床甲减者明显高于对照组(12.00% vs 8.00%，χ2=12.004，P=0.001)。 结论 GDM妊娠早期TSH及FT3水平发生明显改变，孕早期亚临床甲减者发生GDM的风险增高。
, http://www.100md.com
关键词：妊娠期糖尿病；甲状腺功能；亚临床甲减
中图分类号：R714.256 文献标识码：A 文章编号：1006-1959(2017)23-0039-03
Correlation between Thyroid Hormone Levels and Gestational Diabetes Mellitus in Early Pregnancy
DENG Song-qing，CHEN Hai-tian，ZHU Cai-xia，LIU Bin，WANG Dong-yu，WANG Zi-lian
(Department of Obstetrics and Gynecology，the First Affiliated Hospital of Zhongshan University，Guangzhou 510080，Guangdong，China)
, 百拇医药
Abstract：Objective To investigate the early pregnancy and its characteristics of thyroid hormone levels in pregnant women with gestational diabetes mellitus(Gestational diabetes，mellitus，GDM)relationship.Methods Retrospective analysis of January 2012～2013 year in December in the first affiliated hospital of Zhongshan university clinic 4111 cases of pregnant women in pregnancy，and early stage of thyroid hormone levels(TSH，FT3，FT4)detection， OGTT detection 24～28 w of pregnancy.Pregnant women included in the study according to the results of OGTT were divided into GDM group(n=727) and normal control(NGT)group(n=3384).The comparison between two groups of thyroid hormone levels in early pregnancy，early analysis of the relationship between thyroid disease and gestational diabetes.Results GDM group of pregnant women in early pregnancy TSH was significantly lower than the control group[(1.37±0.96)mIU/mlvs(1.53±1.12)mIU/ml，P=0.000)，FT3[(4.75±0.91)mIU/mlvs(4.60±0.73)mIU/ml，P=0.000]was significantly higher than the control group，FT3/FT4(0.35±0.06vs0.34±0.06，P=0.000)have obvious difference two groups of pregnant women.The proportion of early pregnancy subclinical hypothyroidism complicated with GDM 24.37%.GDM composite and subclinical hypothyroidism was significantly higher than the control group(12.00%vs8.00%χ2=12.004，P=0.001).Conclusion The levels of TSH and FT3 in GDM early pregnancy were significantly changed，and the risk of GDM was increased in subclinical hypothyroidism in early pregnancy., http://www.100md.com(邓松清 陈海天 祝彩霞 刘斌 王冬昱 王子莲)
, http://www.100md.com
关键词：妊娠期糖尿病；甲状腺功能；亚临床甲减
中图分类号：R714.256 文献标识码：A 文章编号：1006-1959(2017)23-0039-03
Correlation between Thyroid Hormone Levels and Gestational Diabetes Mellitus in Early Pregnancy
DENG Song-qing，CHEN Hai-tian，ZHU Cai-xia，LIU Bin，WANG Dong-yu，WANG Zi-lian
(Department of Obstetrics and Gynecology，the First Affiliated Hospital of Zhongshan University，Guangzhou 510080，Guangdong，China)
, 百拇医药
Abstract：Objective To investigate the early pregnancy and its characteristics of thyroid hormone levels in pregnant women with gestational diabetes mellitus(Gestational diabetes，mellitus，GDM)relationship.Methods Retrospective analysis of January 2012～2013 year in December in the first affiliated hospital of Zhongshan university clinic 4111 cases of pregnant women in pregnancy，and early stage of thyroid hormone levels(TSH，FT3，FT4)detection， OGTT detection 24～28 w of pregnancy.Pregnant women included in the study according to the results of OGTT were divided into GDM group(n=727) and normal control(NGT)group(n=3384).The comparison between two groups of thyroid hormone levels in early pregnancy，early analysis of the relationship between thyroid disease and gestational diabetes.Results GDM group of pregnant women in early pregnancy TSH was significantly lower than the control group[(1.37±0.96)mIU/mlvs(1.53±1.12)mIU/ml，P=0.000)，FT3[(4.75±0.91)mIU/mlvs(4.60±0.73)mIU/ml，P=0.000]was significantly higher than the control group，FT3/FT4(0.35±0.06vs0.34±0.06，P=0.000)have obvious difference two groups of pregnant women.The proportion of early pregnancy subclinical hypothyroidism complicated with GDM 24.37%.GDM composite and subclinical hypothyroidism was significantly higher than the control group(12.00%vs8.00%χ2=12.004，P=0.001).Conclusion The levels of TSH and FT3 in GDM early pregnancy were significantly changed，and the risk of GDM was increased in subclinical hypothyroidism in early pregnancy., http://www.100md.com(邓松清 陈海天 祝彩霞 刘斌 王冬昱 王子莲)
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