中性粒细胞/淋巴细胞比值、淋巴细胞/中性粒细胞比值与系统性红斑狼疮活动及狼疮肾炎的关系(1)

http://www.100md.com 2017年6月18日 医学信息 2017年第24期

     摘要：目的 探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio，NLR)，淋巴细胞/中性粒细胞比值(lymphocyte to neutrophil ratio，LNR)与系统性红斑狼疮(systemic lupus erythematosus，SLE)疾病活动度、狼疮肾炎的关系。方法 回顾性分析我院SLE患者及健康对照组的资料，评估NLR、LNR与狼疮活动度及狼疮肾炎的关系。结果 37例患者及132例对照组中，有狼疮肾炎23例(占62.16%)，重度活动组20例(占54.05%)。狼疮患者NLR高于對照组(3.71±3.43 VS 1.75±0.63，P=0.000)，LNR低于对照组(0.41±0.26 VS 0.64±0.22，P=0.000)。狼疮肾炎患者NLR高于无狼疮肾炎患者(4.75±3.98 VS 2.00±0.80，P=0.004)，LNR低于无狼疮肾炎患者(0.30±0.16 VS 0.60±0.29，P=0.003)。24 h尿蛋白定量与LNR呈负相关(r=-0.443，P=0.006)。重度活动患者NLR高于非重度活动患者(5.03±4.17 VS 2.15±1.01，P=0.007)，LNR低于非重度活动患者(0.28±0.15 VS 0.57±0.28，P=0.001)。SLEDAI评分与NLR呈正相关(r=0.330，P=0.046)，与LNR呈负相关(r=-0.544，P=0.000)。Logistic分析提示LNR是狼疮肾炎及狼疮重度活动的保护因素。结论 NLR可有效评估狼疮疾病活动度及肾脏受累，LNR是狼疮肾炎与狼疮重度活动的保护因素。
, http://www.100md.com
    关键词：中性粒细胞/淋巴细胞比值；淋巴细胞/中性粒细胞比值；系统性红斑狼疮

    中图分类号：R593.241 文献标识码：A 文章编号：1006-1959(2017)24-0027-04

    The Relationship between Neutrophil/Lymphocyte Ratio，Lymphocyte/Neutrophil Ratio and Systemic Lupus Erythematosus Activity and Lupus Nephritis

    CHANG Jun，SHEN Rong

    (Department of Rheumatology and Immunology，the Second Affiliated Hospital of Nanjing Medical University，Nanjing 210003，Jiangsu，China)
, 百拇医药
    Abstract：Objective To investigate the neutrophil/lymphocyte ratio(neutrophil to lymphocyte ratio，NLR)，the ratio of neutrophils/lymphocytes (lymphocyte to neutrophil ratio，LNR)and systemic lupus erythematosus(systemic lupus erythematosus，SLE)disease activity，the relationship between lupus nephritis.Methods Retrospective analysis of SLE patients and healthy control group the data，assessment of NLR，the relationship between LNR and lupus activity and lupus nephritis.Results 37 cases and 132 cases in the control group，with 23 cases of lupus nephritis(62.16%)，severe group 20 cases(54.05%).The level of NLR in patients with lupus was higher than that in the control group(3.71±3.43vs1.75±0.63，P=0.000)and LNR was lower than that in the control group(0.41±0.26vs0.64±0.22，P=0.000).The level of NLR in patients with lupus nephritis was higher than that in patients without lupus nephritis(4.75±3.98vs2.00±0.80，P=0.004)and LNR was lower than that in patients without lupus nephritis (0.30±0.16vs0.60±0.29，P= 0.003).24 h urinary protein was negatively correlated with LNR(r=-0.443，P=0.006).The level of NLR in patients with severe activity was higher than that in non-severe patients(5.03±4.17vs2.15±1.01，P=0.007)and LNR was lower than that in non-severe patients(0.28±0.15vs0.57±0.28，P=0.001).The SLEDAI score was positively correlated with NLR(r=0.330，P=0.046)and negatively correlated with LNR(r=-0.544，P=0.000).Logistic analysis suggested that LNR was a protective factor for lupus nephritis and severe lupus erythematosus.Conclusion NLR can effectively evaluate the activity of lupus disease and kidney involvement.LNR is a protective factor of lupus nephritis and severe activity of lupus erythematosus., 百拇医药(常俊 谌蓉)

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